放射性肺损伤与转化生长因子-β1/Smads信号通路相关性研究进展  

Correlation between radiation induced lung injury and transforming growth factor-β1/Smads signal pathway

作　　者：张悦 张毅 李金田[1,2] 梁建庆 李娟[3] 马天星 ZHANG Yue;ZHANG Yi;LI Jintian;LIANG Jianqing;LI Juan;MA Tianxing(Clinical College of TCM,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China;Key Laboratory for Dunhuang Medicine and Transformation of Ministry of Education,Lanzhou,Gansu,730000,China;College of Basic Medicine,Gansu University of Chinese Medicine,Lanzhou,Gansu,730101,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730101 [2]敦煌医学与转化教育部重点实验室,甘肃兰州730000 [3]甘肃中医药大学基础医学院,甘肃兰州730101

出　　处：《甘肃中医药大学学报》2022年第4期91-95,共5页Journal of Gansu University of Chinese Medicine

基　　金：国家自然科学基金地区项目(81460695)。

摘　　要：查阅相关文献,对放射性肺损伤(RILI)与转化生长因子-β1(TGF-β1)/Smads信号通路的相关性研究进行概述,明确TGF-β1/Smads信号通路相关蛋白与RILI的关系,从而为RILI的防治提供明确的作用靶点。今后可对TGF-β1/Smads信号通路进行完整时间、不同剂量动态观察,从时间峰值及射线剂量的角度揭示RILI的发病机制,从而为RILI的新药研制提供新思路、新途径。By consulting relevant literature,this paper summarizes the correlation study between radiation induced lung injury( RILI) and transforming growth factor( TGF)-β1/Smads signal pathway,to clarify the relationship between TGF-β1/Smads signaling pathway related proteins and RILI,so as to provide a clear target for the prevention and treatment of the latter. In the future,it is advised to dynamically observe TGF-β1/Smads signal pathway in complete time and different doses to reveal the pathogenesis of RILI from the perspective of time peak and radiation dose,thereby providing new ideas and new ways for the research and development of new drugs for RILI.

关 键 词：放射性肺损伤 转化生长因子-β1/Smads信号通路 相关蛋白 相关性研究 发病机制 防治 综述 

分 类 号：R818.74[医药卫生—放射医学]