木丹颗粒联合前列地尔治疗糖尿病足的临床效果分析  

Clinical Effect of Mudan Granules(木丹颗粒)Combined with Alprostadil in Treatment of Diabetic Foot

作　　者：蒲夏杨 PU Xiayang(Panjin Central Hospital,Panjin 124013,Liaoning,China)

机构地区：[1]盘锦市中心医院,辽宁盘锦124013

出　　处：《辽宁中医杂志》2022年第8期88-91,共4页Liaoning Journal of Traditional Chinese Medicine

摘　　要：目的研究木丹颗粒+前列地尔运用于糖尿病足中的价值。方法选择该院2019年9月—2021年4月纳入的糖尿病足患者106例,按随机数字表法分为两组各53例,双药组服用木丹颗粒+前列地尔,单药组使用前列地尔,测定两组服药前后的空腹血糖、餐后2 h血糖、糖化血红蛋白、炎症指标[白介素细胞-6(IL-6)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)]、氧化应激[丙二醛(MDA)、超氧化物歧化酶(SOD)]指标,服药前后进行临床症状积分调查,对比两组服药前后的溃疡面积、足趾皮肤温度、踝臂指数,比较两组用药结果。结果服药前两组的血糖指标差异无统计学意义(P>0.05),服药后双药组空腹血糖、餐后2 h血糖、糖化血红蛋白低于单药组(P<0.05)。服药前两组症状积分差异无统计学意义(P>0.05),服药后双药组各项评分低于单药组(P<0.05)。服药前两组溃疡面积、足趾皮肤温度、踝臂指数差异无统计学意义(P>0.05),服药后双药组溃疡面积小于单药组,但足趾皮肤温度、踝臂指数高出单药组(P<0.05)。服药前两组炎性反应差异无统计学意义(P>0.05),服药后双药组IL-6、hs-CRP、PCT低于单药组(P<0.05)。服药前两组氧化应激差异无统计学意义(P>0.05),服药后双药组MDA低于单药组,但SOD高出单药组(P<0.05)。结论木丹颗粒+前列地尔在糖尿病足上效果突出,能够稳定血糖,快速缓解症状,消除炎性反应,改善氧化应激,值得推广。Objective To study the value of Mudan Granules(木丹颗粒)and alprostadil in the treatment of diabetic foot.Methods A total of 106 diabetic foot patients enrolled in the hospital from September 2019 to April 2021 were selected and divided into two groups with 53 cases in each group according to the random number table method.The dual-drug group took Mudan Granules and alprostadil,and the single-drug group used alprostadil.The fasting blood glucose,2 h postprandial blood glucose,glycosylated hemoglobin,inflammatory indexes[interleukin-6(IL-6),high sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT)],oxidative stress indicators[malondialdehyde(MDA),superoxide dismutase(SOD)],clinical symptom score survey,the ulcer area,toe skin temperature and ankle brachial index of the two groups before and after taking the medicine were compared.Results There was no difference in blood glucose indexes between the two groups before taking the medicine(P>0.05).The fasting blood glucose,2 h postprandial blood glucose and glycosylated hemoglobin of the dual-drug group after treatment were lower than those of the single-drug group(P<0.05).There was no difference in symptom scores between the two groups before taking the medicine(P>0.05),and the scores of the dual-drug group were lower than those of the single-drug group(P<0.05).There was no difference in ulcer area,toe skin temperature or ankle brachial index between the two groups before taking the medicine(P>0.05).After taking the drug,the ulcer area of the dual-drug group was smaller than that of the single-drug group,but the toe skin temperature and ankle brachial index were higher than those of the single-drug group(P<0.05).There was no difference in the inflammatory reaction between the two groups before taking the medicine(P>0.05),and the levels of IL-6,hs-CRP and PCT in the dual-drug group were lower than those in the single-drug group(P<0.05).There was no difference in oxidative stress between the two groups before taking the medicine(P>0.05).After taking the medicin

关 键 词：糖尿病足 木丹颗粒 炎性反应 前列地尔 

分 类 号：R587.2[医药卫生—内分泌]