微囊泡在肿瘤中的研究进展  

Research progress of microvesicle in tumor

作　　者：谢舟颖 袁一超 熊友香[1] 孙巧仪 朱新悦 张纪平 朱志红[1] XIE Zhou-ying;YUAN Yi-chao;XIONG You-xiang;SUN Qiao-yi;ZHU Xin-yue;ZHANG Ji-ping;ZHU Zhi-hong(Zhejiang University of Chinese Medicine,Hangzhou 311402)

机构地区：[1]浙江中医药大学,杭州311402

出　　处：《中南药学》2022年第8期1757-1764,共8页Central South Pharmacy

基　　金：国家自然科学基金资助项目(No.82003954);浙江中医药大学2020年度校级科研基金项目(No.2019ZG39);浙江中医药大学校级科研基金项目-2019年度国家自然科学基金预研专项(No.2020ZZ08)。

摘　　要：微囊泡是正常生理或病理情况下都会分泌的一种膜性胞外细胞器,不仅可作为新型药物载体,也可在疾病的诊断、预后等方面发挥作用,具有良好的生物相容性、靶向性,并为实施精准医疗提供新的思路。本文通过查阅近年来国内外相关文献,归纳微囊泡分离及纯化的方式和在疾病进程中的阶段性作用,以期为微囊泡的进一步开发利用提供参考。Microvesicles are membranous extracellular organelles secreted under normal physiological or pathological conditions.They can not only be used as new drug carriers,but also play a role in the diagnosis and prognosis of diseases.They have good biocompatibility and targeting,also provide new ideas for the implementation of precision medicine.This paper aimed to provide a reference for the further development and utilization of microvesicles by referring to the relevant literatures home and abroad in recent years,and summarizing the methods of separation and purification of microvesicles and their phased roles in the course of disease.

关 键 词：微囊泡 给药系统 分离与纯化 微囊泡的运用 

分 类 号：R54[医药卫生—心血管疾病]