血清Gal-3、sST2水平对急性ST段抬高型心肌梗死PCI后心力衰竭的预测价值  

Predictive value of serum Gal-3 and sST2 levels on heart failure after PCI in acute ST-segment elevation myocardial infarction

作　　者：周文杰[1] 曹勇[1] 丁晓云[1] 冒晓飚 ZHOU Wenjie;CAO Yong;DING Xiaoyun;MAO Xiaobiao(Department of Cardiovascular Medicine,Rugao People's Hospital,Rugao 226500,China)

机构地区：[1]如皋市人民医院心血管内科,江苏如皋226500

出　　处：《山东医药》2022年第28期29-33,共5页Shandong Medical Journal

基　　金：江苏省医院协会医院管理创新研究立项课题(JSYGY-3-2020-147);南通市卫生健康委员会科研立项课题(MB2021084)。

摘　　要：目的探讨血清半乳糖凝集素3(Gal-3)、可溶性致癌抑制因子2(sST2)水平对急性ST段抬高型心肌梗死(STEMI)经皮冠状动脉介入治疗(PCI)后心力衰竭(HF)的预测价值。方法选择STEMI患者203例,根据PCI后1年内是否并发HF分为并发HF 57例(HF组)、未并发HF 146例(非HF组)。收集所有研究对象PCI后即刻静脉血,离心留取血清,采用ELISA法检测血清Gal-3、sST2。采用多因素Logistic回归模型分析STEMI患者PCI后并发HF的影响因素,采用受试者工作特征(ROC)曲线分析血清Gal-3、sST2水平对STEMI患者PCI后并发HF的预测价值。结果HF组血清Gal-3、sST2水平均显著高于非HF组(P均<0.01)。多因素Logistic回归分析显示,年龄、Gal-3、sST2为STEMI患者PCI后并发HF的独立危险因素,左室射血分数则为其独立保护因素(P均<0.01)。ROC曲线分析显示,血清Gal-3、sST2水平单独及联合预测STEMI患者PCI后并发HF的曲线下面积(AUC)分别为0.786、0.753、0.845,血清Gal-3、sST2水平联合预测STEMI患者PCI后并发HF的AUC高于血清Gal-3、sST2水平单独(P均<0.05)。结论STEMI患者PCI后并发HF者血清Gal-3、sST2水平显著升高;血清Gal-3、sST2水平为STEMI患者PCI后并发HF的独立危险因素,并可作为STEMI患者PCI后并发HF的预测指标。Objective To explore the predictive value of serum galectin 3(Gal-3)and soluble suppression of tumorigenicity-2(sST2)levels on heart failure(HF)after percutaneous coronary intervention(PCI)in patients with acute STsegment elevation myocardial infarction(STEMI).Methods A total of 203 patients with STEMI were selected and divided into HF group(57 cases)and non-HF group(146 cases)according to whether HF occurred within 1 year after PCI.The venous blood was collected from all subjects immediately after PCI,and the serum was collected by centrifugation.Serum Gal-3 and sST2 were detected by ELISA.Multivariate Logistic regression model was used to analyze the influencing factors of HF after PCI in STEMI patients,and receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum Gal-3 and sST2 levels in STEMI patients with HF after PCI.Results The levels of serum Gal-3 and sST2 in the HF group were significantly higher than those in the non-HF group(all P<0.01).Multivariate Logistic regression analysis showed that age,Gal-3 and sST2 were independent risk factors for HF after PCI in STEMI patients,and left ventricular ejection fraction was an independent protective factor(all P<0.01).ROC curve analysis showed that the area under the curve(AUC)of serum Gal-3 and sST2 levels alone and in combination in predicting HF after PCI in STEMI patients were 0.786,0.753,and 0.845,respectively;the AUC of serum Gal-3 and sST2 levels combined in predicting STEMI complicated with HF after PCI was higher than that of serum Gal-3 and sST2 alone(both P<0.05).Conclusion Serum Gal-3 and sST2 levels in STEMI patients with HF after PCI significantly increase;serum Gal-3 and sST2 levels are independent risk factors,and can be used as predictors for STEMI patients with HF after PCI.

关 键 词：急性ST段抬高型心肌梗死 心力衰竭 半乳糖凝集素3 可溶性致癌抑制因子2 

分 类 号：R541[医药卫生—心血管疾病]