新型吡唑肟衍生物的设计、合成与杀虫活性  

Design,Synthesis and Insecticidal Activity of Novel Pyrazole Oxime Derivatives

作　　者：张紫婵 郑丹丹 石玉军[1] 丁颖 李建华[1] 严瑞健 张敏 王杨 戴红[1] ZHANG Zichan;ZHENG Dandan;SHI Yujun;DING Ying;LI Jianhua;YAN Ruijian;ZHANG Min;WANG Yang;DAI Hong(College of Chemistry and Chemical Engineering,Nantong University,Nantong 226019,China)

机构地区：[1]南通大学化学化工学院,江苏南通226019

出　　处：《合成化学》2022年第9期749-755,共7页Chinese Journal of Synthetic Chemistry

基　　金：南通市科技计划(MS22020024)。

摘　　要：为寻找高效与低毒的吡唑肟活性物质,设计、合成了9个未见文献报道的吡唑肟化合物6a~6i,并通过^(1)H NMR、^(13)C NMR及元素分析等方法表证了其目标物的结构。初步生物活性测试数据显示,在500μg/mL浓度下,目标化合物6a~6i对粘虫均有较好的杀灭效果,杀死率均为100%,与对照药啶虫丙醚的杀虫效果相当,值得进一步深入研究。To find new pyrazole oximes with excellent bioactivities and low toxicity,nine novel pyrazole oxime derivatives were synthesized.The structures of the aimed compounds were characterized through ^(1)H NMR,^(13)C NMR and elemental analysis.Preliminary bioassay data displayed that at the concentration of 500 μg/mL,all the title compounds 6 a~6 i showed 100% insecticidal activities against Oriental armyworm,which were comparable to the commercial insecticide Pyridalyl.These compounds may be selected as lead compounds for further study.

关 键 词：吡唑肟 设计合成 杀虫活性 

分 类 号：O626.2[理学—有机化学]