抗菌肽的结构修饰及活性研究进展  

Research Progress on Structural Modification and Activity of Antimicrobial Peptides

作　　者：段丛雪 王彬 王珊珊 陈旺 冯自立[1,2] DUAN Cong-xue;WANG Bin;WANG Shan-shan;CHEN Wang;FENG Zi-li(School of Bioscience and Engineering,Shanxi University of Technology,Hanzhong 723000,China;State Key Laboratory of Qinba Bioresources and Eco-Environment,Shanxi University of Technology,Hanzhong 723000,China)

机构地区：[1]陕西理工大学生物科学与工程学院,陕西汉中723000 [2]陕西理工大学秦巴生物资源与生态环境省部共建国家重点实验室,陕西汉中723000

出　　处：《化学试剂》2022年第10期1411-1420,共10页Chemical Reagents

基　　金：陕西理工大学博士启动基金项目(SLGQD2017-11);陕南秦巴山区生物资源综合开发协同创新中心产业化培育项目(QBXT-18-1)。

摘　　要：抗生素耐药性是目前急需解决的医疗问题之一,寻找新的有效抗菌药物是解决耐药性的一种有效途径。抗菌肽(Antimicrobial peptides,AMPs)是广泛存在于生物体内的一类重要的多肽活性物质,具有广谱抗菌活性,并且部分抗菌肽还具有一定的抗肿瘤活性。因为抗菌肽具有独特的破膜作用机制,传统的耐药机制难以对其产生影响,在治疗细菌感染方面有广阔的应用前景,因此得到了研究者的广泛关注。主要通过总结相关研究文献,对抗菌肽的研究现状以及结构改造的研究加以综述,为抗菌肽在临床上的进一步研究和开发提供参考。Antibiotic resistance was one of the medical problems that need to be solved urgently.Finding new effective antibiotics was an effective way to solve drug resistance.Antimicrobial peptides(AMPs)were a kind of important polypeptide active substances widely existing in organisms.They had broad-spectrum antibacterial activity,and some antimicrobial peptides also had certain antitumor activity.Because antimicrobial peptides had a unique membrane breaking mechanism,the traditional drug resistance mechanism was difficult to affect them.They had broad application prospects in the treatment of bacterial infection,so they had attracted extensive attention of researchers.The relevant research literatures,the research status of antimicrobial peptides and the research of structural transformation were summarized,so as to provide reference for the further research and development of antimicrobial peptides in clinic.

关 键 词：抗生素 耐药性 抗菌肽 结构修饰 抗菌活性 

分 类 号：TQ465.6[化学工程—制药化工]