糖尿病及其大血管病变证候要素分布特征文献研究  

Literature Study on Distribution Characteristics of Traditional Chinese Medicine Syndrome Elements of Diabetes and Diabetic Macroangiopathy

作　　者：冷玉琳 富晓旭[1] 高泓[1] 徐刚 卓兴卫 刘汉宇 谢春光[1] Leng Yulin;Fu Xiaoxu;Gao Hong;Xu Gang;Zhuo Xingwei;Liu Hanyu;Xie Chunguang(Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu,610075,China)

机构地区：[1]成都中医药大学附属医院,四川成都610075

出　　处：《成都中医药大学学报》2022年第3期98-103,共6页Journal of Chengdu University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81703953);四川省科技厅重点研发项目重大专项(2019YFS0022);四川省中医药管理局中医药科学技术研究专项(2018LC016)。

摘　　要：目的:总结糖尿病及其大血管病变的证候要素分布特征,为临床辨治及证候临床研究提供参考。方法:检索CNKI、CBM、VIP等数据库自建库以来至2017年12月31日的糖尿病及其大血管病变中医文献,提取文献四诊资料、证候要素、证候要素靶位等信息,进行数据规范化及统计分析。结果:共纳入合格文献335篇,其中糖尿病本病期文献287篇,累计提取889个证型,1544个证候要素,504个证候要素靶位,6190个四诊条目;糖尿病大血管病变文献48篇,累计提取205个证型,378个证候要素,67个证候要素靶位,1572个四诊条目。本病期常见证候要素依次为阴虚、气虚、实热、痰湿,大血管病变常见证候要素依次为阴虚、血瘀、气虚、痰湿;本病期常见证候要素靶位依次为肾、脾、胃,大血管病变常见证候要素靶位依次为脉、脾、肾;本病期常见高频症状依次为口干口渴、乏力、多饮、多尿、尿频,大血管病变常见高频症状依次为肢体疼痛、乏力、口干口渴、心悸、头晕,与本病期表征差异显著。结论:阴虚、气虚是由糖尿病本病期进展至大血管病变阶段的贯穿疾病全程的基本证候要素,随疾病进展临床症状谱复杂化、多样化,痰湿、血瘀逐渐加重,呈由虚致实、虚实夹杂的证候特点;糖尿病大血管并发症病位在脉,病变脏腑与脾、肾相关。Objective:Summarize the distribution characteristics of Traditional Chinese Medicine(TCM)syndromes of diabetes and its macroangiopathy diseases,so as to provide references for clinical treatment and clinical research of syndromes.Methods:Traditional Chinese medicine literature on diabetes and its macroangiopathy diseases was searched from CNKI,CBM,VIP databases from their establishment to December 31,2017 to extract the four diagnosis data,syndrome elements,target of syndrome elements and other information,and the data was standardized and statistically analyzed.Results:A total of 335 qualified literatures were included,including 287 literatures of diabetes in this period and 48 literatures of diabetic macroangiopathy.A total of 889 syndrome types,1544 syndrome elements,504 targets of syndrome elements,and 6190 four-diagnosis items were extracted from the literature during diabetes period.205 syndrome types,378 syndrome elements,67 targets of syndrome elements,and 1572 four-diagnosis items were extracted from the literature of macroangiopathy diseases.In diabetes disease stage,the factors of common syndromes were Yin deficiency,Qi deficiency,solid Heat and phlegm Dampness in order,while those of major vascular diseases were Yin deficiency,Blood stasis,Qi deficiency and phlegm Dampness in order.In diabetes disease stage,the targets of common syndromes were Kidney,Spleen and Stomach,and in macroangiopathy disease stage,the targets of common syndromes were Pulse,Spleen and Kidney.The first five high-frequency symptoms of diabetes disease stage were thirst,fatigue,polyuria,polyuria,and frequent urination,respectively.The high-frequency symptoms of macroangiopathy disease stage were limb pain,fatigue,thirst,palpitations,and dizziness,respectively.Conclusion:The distribution characteristics of syndrome elements in diabetes from the disease stage to macroangiopathy stage are mainly Yin deficiency and Qi deficiency.With the disease progression,the clinical symptoms are gradually complicated and diversified,and phlegm Dam

关 键 词：糖尿病大血管病变 证候要素 证候要素靶位 文献研究 

分 类 号：R587.2[医药卫生—内分泌] R255.4[医药卫生—内科学]