血清尿酸水平与缓慢性心律失常的相关性研究  

Relationship between serum uric acid level and bradyarrhythmia

作　　者：董海翠 方旭[1] 杨吉猛 俞娅娅 韦存胜[1] 王君[1] DONG Haicui;FANG Xu;YANG Jimeng;YU Yaya;WEI Cunsheng;WANG Jun(Department of Cardiology,The Affiliated Jiangning Hospital of Nanjing Medical University,Nanjing 211100,China)

机构地区：[1]南京医科大学附属南京市江宁医院心内科,江苏南京211100

出　　处：《沈阳医学院学报》2022年第5期484-487,492,共5页Journal of Shenyang Medical College

摘　　要：目的:探讨血清尿酸(serum uric acid,SUA)水平与缓慢性心律失常发病的相关性。方法:选择2017年1月至2020年12月我院心血管内科收治的144例缓慢性心律失常患者为研究组,其中房室传导阻滞(atrioventricular block,AVB)患者104例(Ⅰ度、Ⅱ度和Ⅲ度AVB患者分别为22、23和59例),病态窦房结综合征(sick sinus syndrome,SSS)患者40例;选择同期体检科144例健康体检者为对照组。回顾性分析人口统计学信息、生化检查指标、心脏彩超等资料。采用Logistic回归分析方法探讨SUA水平与AVB和SSS的相关性。结果:研究组的SUA水平明显高于对照组(P<0.01)。Ⅲ度AVB患者SUA水平明显高于对照组(P<0.01);Ⅰ度和Ⅱ度AVB以及SSS患者的SUA水平与对照组比较差异无统计学意义(P>0.05)。高尿酸血症(hyperuricemia,HUA)与缓慢性心律失常具有显著相关性(OR=5.19,95%CI:2.40~11.22,P<0.01)。对年龄、性别、糖尿病、总胆固醇、低密度脂蛋白胆固醇、血清肌酐、血红蛋白、射血分数等潜在混杂因素进行逐步调整后,HUA仍与缓慢性心律失常具有显著相关性(OR=4.18,95%CI:1.63~10.70,P=0.003)。结论:SUA水平和HUA均与缓慢性心律失常发病具有显著相关性。SUA水平与Ⅲ度AVB具有显著相关性,与Ⅰ度、Ⅱ度AVB以及SSS未见明显相关性。Objective:To investigate the relationship between serum uric acid(SUA)level and bradyarrhythmia.Methods:A total of 144 hospitalized patients with bradyarrhythmia admitted to the Department of Cardiology in our hospital from Jan2017 to Dec 2020 were selected as the case group.Among these patients,104 and 40 patients suffered from atrioventricular block(AVB)and sick sinus syndrome(SSS),respectively.The first-degree,second-degree,and third-degree AVB patients were 22,23,and 59 cases,respectively.And 144 healthy subjects in the Department of Physical Examination during the same period were selected as the control group.The demographic information,biochemical examination indexes and cardiac ultrasound were analyzed retrospectively.The relationship of SUA with AVB and SSS was evaluated by logistic regression analysis.Results:The SUA level in the case group was higher than that in the control group(P<0.01).The SUA level in patients with third-degree AVB was remarkably elevated compared with that in the control group(P<0.01).In contrast,there were no statistical differences in SUA levels for first-degree AVB,second-degree AVB,and SSS patients compared with the control group(P>0.05).Hyperuricemia(HUA)was significantly associated with bradyarrhythmia before and even after adjustments of potential confounders such as age,gender,diabetes,total cholesterol,low-density lipoprotein cholesterol,serum creatinine,hemoglobin,and ejection fraction(before:OR=5.19,95%CI:2.40-11.22,P<0.01;after:OR=4.18,95%CI:1.63-10.70,P=0.003).Conclusions:SUA level and HUA have significant correlations with bradyarrhythmia.The SUA level is significantly correlated with the third-degree AVB,but not with first-degree AVB,second-degree AVB and SSS.

关 键 词：尿酸 缓慢性心律失常 房室传导阻滞 病态窦房结综合征 

分 类 号：R541.7[医药卫生—心血管疾病]