补肺舒喘汤治疗哮喘慢性持续期肺肾阳虚证的疗效分析及对T淋巴细胞亚群的影响  

The curative effect of the Bufei Shuchuan decoction on the Yang-deficiency of lung and kidney type chronic persistent asthma and its influences on T lymphocyte subsets

作　　者：张建生 王庆 朱烨芳 刘宏波 ZHANG Jiansheng

机构地区：[1]福建中医药大学附属第三人民医院,福建福州350108

出　　处：《中医临床研究》2022年第23期122-127,共6页Clinical Journal Of Chinese Medicine

基　　金：福建中医药大学校管课题资助(XB2020035)。

摘　　要：目的:探讨补肺舒喘汤治疗哮喘慢性持续期肺肾阳虚证的疗效及对T淋巴细胞亚群(CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+))的影响。方法:筛选2020年10月-2021年10月就诊于福建中医药大学附属第三人民医院呼吸科门诊符合纳入标准的60例患者,随机分为治疗组和对照组各30例。对照组给予布地奈德福莫特罗粉吸入剂治疗,治疗组在对照组基础上联合补肺舒喘汤颗粒剂治疗。两组均治疗30 d,治疗结束后门诊随访30 d。比较两组临床疗效、中医证候积分、肺功能指标、T淋巴细胞亚群(CD4^(+)、CD8^(+)和CD4^(+)/CD8^(+))、治疗期间及随访期间急性发作次数和沙丁胺醇吸入总掀数。结果:治疗组的总有效率高于对照组,差异有统计学意义(P<0.05)。治疗后两组中医证候积分均较前降低,哮喘控制测试(Asthma Control Test,ACT)评分均较前增高,且治疗组改善程度均优于对照组,差异有统计学意义(P<0.05)。治疗后两组肺功能指标均较前有所改善,且治疗组改善程度均优于对照组,差异有统计学意义(P<0.05)。治疗后两组CD4^(+)、CD4^(+)/CD8^(+)均较前降低,CD8^(+)均较前升高,且治疗组改善程度均优于对照组,差异有统计学意义(P<0.05)。治疗期间及治疗结束后随访期间,治疗组患者哮喘急性发作次数与对照组相比均有所减少,差异有统计学意义(P<0.05)。两组患者治疗期间沙丁胺醇吸入总掀数对比,差异无统计学意义(P>0.05);治疗结束后随访期间,治疗组沙丁胺醇吸入总掀数与对照组相比有所减少,差异有统计学意义(P<0.05)。结论:补肺舒喘汤治疗哮喘慢性持续期肺肾阳虚证疗效明显,能有效改善患者的中医证候、肺功能及T淋巴细胞亚群水平,减少急性发作次数,降低后期复发频率,使哮喘得到有效控制。Objective:To investigate the effect of the Bufei Shuchuan decoction(补肺舒喘汤)on the Yang-deficiency(阳虚)of lung and kidney type chronic persistent asthma and its influences on T lymphocyte subsets(CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)).Methods:A total of 60 cases that met the inclusion criteria from October 2020 to October 2021 were selected and randomly divided into the treatment group and the control group,with 30 cases in each group.The control group was treated with budesonide formoterol powder inhalation,and the treatment group was additionally treated with the Bufei Shuchuan decoction granules.Both groups were treated for 30 days and followed up for 30 days after treatment.Results:The total efficiency in the treatment group was higher than the control group,and the difference was statistically significant(P<0.05).After treatment,TCM syndrome scores in both groups were decreased,and ACT scores were increased,and the change in the treatment group was better than the control group,with a statistically significant difference(P<0.05).After treatment,the pulmonary function indicators in the two groups were all ameliorated,and the change in the treatment group was better than the control group(P<0.05).After treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in both groups were lower than before,while the levels of CD8^(+)in both groups were higher than before,and the changes in the treatment group were better than the control group(P<0.05).The number of acute asthma attacks in the treatment group was reduced compared with the control group during the treatment period and followed-up period after treatment,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the total number of inhaled salbutamol between the groups during treatment(P>0.05).During the followed-up period after treatment,the total number of inhaled salbutamol in the treatment group was decreased compared with the control group(P<0.05).Conclusion:The Bufei Shuchuan decoction shows an obviou

关 键 词：补肺舒喘汤 支气管哮喘 慢性持续期 T淋巴细胞亚群 

分 类 号：R256.12[医药卫生—中医内科学]