探讨恶性肿瘤患者血栓弹力图(TEG)以及常规凝血指标的变化  

Investigation on the Changes of Thromboelastography(TEG)and Routine Coagulation Indexes in Patients with Malignant Tumor

作　　者：沈蓉[1] SHEN Rong(Department of Blood Transfusion,Qidong People's Hospital,Qidong,Jiangsu Province,226200 China)

机构地区：[1]启东市人民医院输血科,江苏启东226200

出　　处：《系统医学》2022年第15期99-102,共4页Systems Medicine

摘　　要：目的探讨恶性肿瘤患者血栓弹力图(thrombelastograghy,TEG)以及常规凝血指标的变化。方法选取2020年10月—2021年6月启东市人民医院收治的恶性肿瘤患者89例,均为其开展TEG与常规凝血指标检测,对TEG检测与常规凝血指标检测各指标开展相关性分析,并分析TEG联合常规凝血指标预测恶性肿瘤患者血栓发生风险的效果。结果R与APTT为正相关,与PT无明显相关性;K与FIB为负相关,K值缩短,FIB值增大;MA与FIB为正相关,MA值增大,FIB值增大;一致性分析显示,R、K及MA与凝血结果之间具备较好的一致性,差异有统计学意义(P<0.05);PT、APTT与FIB与凝血结果之间的一致性分析,差异无统计学意义(P>0.05);TEG联合常规凝血指标预测恶性肿瘤患者血栓的灵敏度为67%,特异度为52%。结论TEG与常规凝血检测具备明显相关性,但不具备较高的吻合度,无法替代应用,TEG联合常规凝血指标在恶性肿瘤患者血栓发生风险预测中具备一定作用。Objective To investigate the changes of thromboelastography(TEG)and routine coagulation indexes in pa⁃tients with malignant tumors.Methods A total of 89 patients with malignant tumors admitted to Qidong People's Hos⁃pital from October 2020 to June 2021 were selected and tested for TEG and conventional coagulation indexes.To ana⁃lyze the correlation between TEG detection and conventional coagulation indexes,and to analyze the effect of TEG combined with conventional coagulation indexes in predicting the risk of thrombosis in patients with malignant tumors.Results R was positively correlated with APTT,but had no significant correlation with PT.K was negatively correlated with FIB,and the value of K shortened and the value of FIB increased.MA and FIB showed a positive correlation,MA value increased,FIB value increased.The consistency analysis showed that R,K and MA had good consistency with the coagulation results,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the consistency of PT,APTT,FIB and coagulation results(P>0.05).The sensitivity and specificity of TEG combined with conventional coagulation indicators in predicting thrombosis in patients with malignant tumors were 67%and 52%.Conclusion TEG has obvious correlation with conventional coagulation detection,but it does not have a high degree of agreement and cannot be used as a substitute for application.TEG combined with conventional coagulation indicators has a certain role in predicting the risk of thrombosis in patients with malignant tumors.

关 键 词：恶性肿瘤 血栓弹力图 常规凝血指标 相关性 高凝状态 血栓 

分 类 号：R446[医药卫生—诊断学]