高渗糖点眼联合局部给氧治疗白内障术后重度角膜水肿的效果分析  

Effect of Hypertonic Glucose Eye Drops combined with Local Oxygen in the Treatment of Severe Corneal Edema after Cataract Surgery

作　　者：唐海霞[1] 李梦琪[1] 李璇[1] 应阿珣 TANG Haixia;LI Mengqi;LI Xuan;YING Axun(Department of Ophthalmology,Shinan District People's Hospital,Qingdao,Shandong Province,266071 China)

机构地区：[1]青岛市市南区人民医院眼科,山东青岛266071

出　　处：《系统医学》2022年第16期55-58,68,共5页Systems Medicine

摘　　要：目的 分析白内障术后重度角膜水肿应用高渗糖点眼与局部给氧治疗的效果。方法 将青岛市市南区人民医院2019年1月—2021年4月收治的120例白内障术后重度角膜水肿患者,采用奇偶数分组法随机分为对照组(60例)与研究组(60例),前者采用高渗糖点眼治疗,后者采用高渗糖点眼与局部给氧治疗。评估患者临床症状改善情况、角膜中央厚度、最佳矫正视力(BCVA)、角膜内皮细胞计数、临床治疗效果。结果 治疗后研究组角膜水肿消退时间为(10.98±1.12)d、角膜中央厚度为(583.61±23.16)μm,对照组角膜水肿消退时间为(14.27±4.92)d,角膜中央厚度为(550.76±18.52)μm。研究组角膜水肿消退时间短于对照组,且角膜中央厚度高于对照组,差异有统计学意义(t=5.051、8.581,P<0.001);治疗后7 d研究组BCVA为(0.79±0.23)、角膜内皮细胞计数为(2 438.65±364.82)个/mm^(2),对照组BCVA为(0.51±0.12),角膜内皮细胞计数为(2 301.86±342.61)个/mm^(2),研究组BCVA及角膜内皮细胞计数均高于对照组,差异有统计学意义(t=8.360、2.117,P<0.05);研究组治疗总有效率为98.33%,对照组治疗总有效率为86.67%,研究组治疗总有效率高于对照组,差异有统计学意义(χ^(2)=4.324,P=0.038)。结论 白内障术后重度角膜水肿应用高渗糖点眼与局部给氧治疗效果更佳,可有效缩短临床症状持续时间,提高患者视力水平。Objective To analyze the effect of hypertonic glucose eye drops and local oxygen therapy for severe corneal edema after cataract surgery.Methods A total of 120 patients with severe corneal edema after cataract surgery who were admitted to Qingdao Shinan District People’s Hospital from January 2019 to April 2021 were selected as the research subjects. They were randomly divided into the control group(60 cases) and the study group(60 cases) by the odd-even grouping method. The former was treated with hypertonic glucose eye drops, while the latter was treated with hypertonic glucose eye drops and local oxygen therapy. The improvement of clinical symptoms, central corneal thickness, best corrected visual acuity(BCVA), corneal endothelial cell count and clinical treatment effect were evaluated.Results After treatment, the corneal edema subsided time in the study group was(10.98±1.12) d, the central corneal thickness was(583.61±23.16) μm. In the control group, the corneal edema subsided time was(14.27±4.92) d, the central corneal thickness was(550.76±18.52) μm, the corneal edema subsidence time in the study group was shorter than that in the control group, and the central corneal thickness was higher than that in the control group, and the difference was statistically significant(t=5.051, 8.581, P<0.001). 7 d after treatment, the BCVA of the study group was(0.79±0.23), the corneal endothelial cell count was(2 438.65±364.82) cells/mm^(2), the BCVA of the control group was(0.51±0.12), the corneal endothelial cell count was(2 301.86±342.61) cells/mm^(2), the BCVA and corneal endothelial cell counts in the study group were higher than those in the control group, and the difference was statistically significant(t=8.360, 2.117, P<0.05). The total effective rate was 98.33% in the study group and 86.67% in the control group. The total effective rate in the study group was higher than that in the control group, and the difference was statistically significant(χ^(2)=4.324, P=0.038).Conclusion Hyperosmolar sugar spot

关 键 词：白内障手术 角膜水肿 高渗糖点眼 局部给氧 治疗效果 

分 类 号：R521[医药卫生—内科学]