HPV联合TCT检查应用于宫颈癌筛查的临床意义  

Clinical Significance of HPV Combined with TCT in Cervical Cancer Screening

作　　者：陈君茹[1] 霍小兵[1] 李丽[1] CHEN Junru;HUO Xiaobing;LI Li(Department of Laboratory,Taixing Hospital of Traditional Chinese Medicine,Taixing,Jiangsu Province,225400 China)

机构地区：[1]泰兴市中医院检验科,江苏泰兴225400

出　　处：《系统医学》2022年第16期169-172,共4页Systems Medicine

摘　　要：目的 探讨人乳头瘤病毒(human papillomavirus,HPV)联合液基薄层细胞检测(thinprep cytologic test,TCT)检测在宫颈癌筛查中的应用价值。方法 选择泰兴市中医院2019年1月—2021年6月进行宫颈癌筛查的患者65例,均开展HPV、TCT以及病理检查,以病理检查结果为金标准,分析HPV、TCT单独检查的准确率、特异度、灵敏度,并将其与HPV、TCT联合检查的结果进行对比分析,评估联合检查的诊断效能。结果 病理检查结果证实阳性36例,阴性29例。HPV单独诊断准确率、灵敏度、特异度分别为75.38%、83.33%、65.52%,TCT单独检验准确率、灵敏度、特异度分别为80.00%、86.11%、72.41%,HPV联合TCT检测的准确率87.69%、灵敏度83.33%、特异度93.10%。联合检测诊断准确率、特异度87.69%、93.10%,高于HPV检查的75.38%、65.52%,联合检测检查特异度高于TCT检查的72.41%,差异有统计学意义(χ^(2)=6.125、6.125、4.167,P<0.05)。结论 在宫颈癌筛查中采用HPV联合TCT检查能够提高对宫颈癌及其癌前病变诊断的准确性,诊断效能高,能够为宫颈癌的早期诊断与治疗提供可靠依据。Objective To explore the application value of human papillomavirus(HPV) combined with liquid-based thin-layer cytometry(TCT) detection in cervical cancer screening.Methods A total of 65 patients who underwent cervical cancer screening in Taixing Hospital of Traditional Chinese Medicine from January 2019 to June 2021 were selected. HPV, TCT and pathological examinations were carried out. Using pathological examination results as the gold standard, the accuracy, specificity, and sensitivity of HPV and TCT examinations alone were analyzed. It was compared with the results of HPV and TCT combined inspection to evaluate the diagnostic efficacy of the combined inspection.Results Pathological examination results confirmed positive in 36 cases and negative in 29 cases. The diagnostic accuracy, sensitivity and specificity of HPV alone were 75.38%, 83.33%, and 65.52%, respectively, the accuracy, sensitivity and specificity of TCT alone were 80.00%, 86.11%, and 72.41%, respectively. The accuracy of HPV combined with TCT detection was 87.69%, the sensitivity was 83.33%, and the specificity was 93.10%. The diagnostic accuracy and specificity of combined detection were 87.69% and 93.10%, which were higher than 75.38% and65.52% of HPV detection. The specificity of combined detection was 72.41% higher than that of TCT, and the difference was statistically significant(χ^(2)=6.125,6.125,4.167,P<0.05).Conclusion The use of HPV combined with TCT in cervical cancer screening can improve the accuracy of the diagnosis of cervical cancer and its precancerous lesions,with high diagnostic efficiency, and can provide a reliable basis for the early diagnosis and treatment of cervical cancer.

关 键 词：HPV TCT 宫颈癌筛查 诊断效能 

分 类 号：R446[医药卫生—诊断学]