国医大师张震舒调气机治疗对Ⅱ、Ⅲ期肺癌患者预后影响的回顾性队列研究  

A retrospective cohort study on the influence of TCM master ZHANG Zhen’s regulating Qi therapy on the prognosis of patients with lung cancer in stage Ⅱ and Ⅲ

作　　者：晏玉武 林德潮 许炜望 马燕妮 魏玖月[1] 武彦琴 易小玲[1] YAN Yuwu

机构地区：[1]昆明市中医医院,云南昆明650500

出　　处：《中医临床研究》2022年第25期31-35,共5页Clinical Journal Of Chinese Medicine

基　　金：昆明市科技局科技计划项目(2019-1-S-25318000001542)。

摘　　要：目的:本研究主要探讨国医大师张震舒调气机治疗对原发性非小细胞肺癌(Non-Small Cell Lung Cancer,NSCLC)术后复发转移的影响。方法:采用回顾性队列研究的方法,以中医药治疗在2016年9月1日-2019年9月1日的原发性NSCLC患者为研究对象,服用中药为暴露因素,将研究对象根据中药治疗时间分为高暴露组、低暴露组和无暴露组3个队列,采用流式细胞技术检测研究对象血清CD4^(+)、CD8^(+)T细胞分布。结果:共计纳入患者360例,其中高暴露组128例、低暴露组118例、无暴露组114例,三个观察组治疗6个月主症评分均较前明显降低;高暴露组下降分值最显著,与其他两组比较有显著差异。高暴露组复发转移率明显低于无暴露组。COX多因素回归分析提示暴露因素为保护因素。结论:对于Ⅱ、Ⅲ期原发性NSCLC患者,国医大师张震舒调气机治疗可以减少肿瘤的复发转移。Objective:To explore the influence of regulating Qi(气)activity therapy created by TCM master ZHANG Zhen on postoperative recurrence and metastasis in primary NSCLC patient.Methods:Primary NSCLC patients treated in TCM from September 1,2016 to September 1,2019 were recruited in the study for a retrospective cohort analysis.Taking ingestion of TCM medicine as the exposure factor,the research subjects were classified to the high-exposure group,the low-exposure group and the none-exposure group according to the TCM treatment time.The distribution of serum CD4^(+) and CD8^(+) T cells in the research subject was detected by flow cytometry.Results:A total of 360 eligible NSCLC patients were recruited,with 128 cases in the high-exposure group,with 118 cases in the low-exposure group and 114 cases in the none-exposure group.After 6 months of treatment,the main symptom score in the three groups were all significantly reduced compared with before.The score in the high-exposure group was decreased most significantly,and there was a significant difference compared with the other two groups.The recurrence and metastasis rate in the high-exposure group was significantly lower than that in the none-exposure group.COX multivariate regression analysis demonstrated that the exposure factor(TCM intervention)was the protective factor of NSCLC patient.Conclusion:For patients with stage Ⅱ and Ⅲ primary NSCLC,the regulating Qi activity from TCM master ZHANG Zhen can reduce the recurrence and metastasis.

关 键 词：原发性非小细胞肺癌 复发转移 舒调气机治疗 流式细胞技术 队列研究 

分 类 号：R273[医药卫生—中西医结合]