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作 者:李莉[1] 徐运升 赵云燕[1] 戚淑娟[1] LI Li
机构地区:[1]广东省广州市中医医院,广东广州510130 [2]广州中医药大学第一附属医院,广东广州510405
出 处:《中医临床研究》2022年第26期105-107,共3页Clinical Journal Of Chinese Medicine
基 金:广州市医药卫生科技项目(20162A011007)。
摘 要:目的:探讨补中益气汤联合肠内营养对老年危重症患者免疫功能的影响及其作用机制。方法:将100例老年危重症患者随机分为对照组和治疗组,每组50例。对照组接受常规对症及肠内营养支持等治疗,治疗组在对照组治疗的基础上用补中益气汤鼻饲。比较两组患者治疗前后体液免疫指标(免疫球蛋白G、免疫球蛋白A、免疫球蛋白M、补体C3、补体C4)、细胞免疫指标(CD3^(+)、CD4^(+)、CD8^(+)、NK)及胃肠道不良反应发生率。结果:治疗后,两组患者的体液免疫指标及细胞免疫指标CD3^(+)、CD4^(+)、NK水平均高于治疗前,且观察组免疫球蛋白A、免疫球蛋白M、补体C3、补体C4、CD3^(+)、CD4^(+)、NK等改善较对照组明显,差异有统计学意义(P <0.05);治疗组胃肠道不良反应更少,差异有统计学意义。结论:补中益气汤联合肠内营养能够改善危重症患者的免疫功能,减少胃肠道不良反应发生率。Objective:To explore the influences of the Buzhong Yiqi decoction(补中益气汤)plus enteral nutrition on immune function of elderly critically ill patients.Methods:A total of 100 cases were randomized divided into two groups,with 50 cases in each group.The two groups were given routine symptomatic treatment and enteral nutrition support,and the observation group was additionally given the Buzhong Yiqi decoction by nasal feeding.Results:After treatment,the levels of humoral immune indicators(immunoglobulin G,immunoglobulin A,immunoglobulin M,C3,C4)and cellular immune indicators(CD3+,CD4+,CD8+,NK)in the two groups were all higher than those before treatment(P<0.05).In addition,the amelioration of immunoglobulin A,immunoglobulin M,C3,C4,CD3+,CD4+,and NK cell in the observation group was significantly higher than the control group,and the difference was statistically significant(P<0.05).The treatment group showed fewer gastrointestinal adverse reactions,with a statistically significant difference between the groups.Conclusion:The Buzhong Yiqi decoction plus enteral nutrition can improve immune function of elderly critically ill patients,and reduce the incidence of gastrointestinal adverse reactions.
分 类 号:R259[医药卫生—中西医结合]
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