铜绿假单胞菌噬菌体与宿主的相互作用研究进展  

Research advances on the interaction between Pseudomonas aeruginosa bacteriophages and the host

作　　者：石茜 曾茁 张一鸣 杨子晨 彭毅志 Shi Xi;Zeng Zhuo;Zhang Yiming;Yang Zichen;Peng Yizhi(Department of Plastic and Cosmetic Surgery,the Second Affiliated Hospital of Army Medical University(the Third Military Medical University),Chongqing 400037,China;State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Burn Research,the First Affiliated Hospital of Army Medical University(the Third Military Medical University),Chongqing 400038,China)

机构地区：[1]陆军军医大学(第三军医大学)第二附属医院整形美容外科,重庆400037 [2]陆军军医大学(第三军医大学)第一附属医院全军烧伤研究所,创伤、烧伤与复合伤国家重点实验室,重庆400038

出　　处：《中华烧伤与创面修复杂志》2022年第9期849-853,共5页Chinese Journal of Burns And Wounds

基　　金：国家自然科学基金面上项目(81772073);国家自然科学基金青年科学基金项目(82002051);创伤、烧伤与复合伤国家重点实验室开放课题基金(SKLKF201918);重庆市自然科学基金面上项目(cstc2021jcyj-msxmX0655);重庆市博士“直通车”项目(CSTB2022BSXM-JCX0019)。

摘　　要：铜绿假单胞菌是最常见的烧伤感染创面病原菌,它能够编码多种毒力因子,具有很强的致病性,可导致预后差、病死率高。为了研究对抗铜绿假单胞菌感染的新方法,研究者们观察了其噬菌体与宿主之间广泛的相互作用。噬菌体通过多种机制影响甚至主导宿主细菌的结构、运动、代谢,促进宿主进化,也是影响宿主环境适应性和致病性的重要因素。该文分别从单细胞水平和群体水平对铜绿假单胞菌噬菌体与宿主的相互作用进行了综述。了解这些相互作用可为铜绿假单胞菌临床感染的治疗研究提供新的思路,为未来研发抗菌制剂以及指导烧伤感染治疗提供基础。Pseudomonas aeruginosa is the most common pathogen of burn wound infection.It can encode a variety of virulence factors and is highly pathogenic,which can lead to poor prognosis and high mortality.In order to research a new method to combat Pseudomonas aeruginosa infection,researchers have observed a wide range of interactions between the bacteriophages and the host.Bacteriophages influence and even dominate the structure,movement,and metabolism of host bacteria through a variety of mechanisms,catalyze the evolution of the host,and are also an important factor in host environmental adaptability and pathogenicity.In this paper,the interaction between Pseudomonas aeruginosa bacteriophages and the host is reviewed from the single cell level and the population level.Understanding these interactions could provide new idea for the treatment of Pseudomonas aeruginosa clinical infections,provides a basis for future development of antimicrobial agents and guides the treatment of burn infections.

关 键 词：铜绿假单胞菌 细菌噬菌体 宿主与病原体相互作用 烧伤 感染 

分 类 号：R378[医药卫生—病原生物学]