白细胞介素6在增生性瘢痕形成中的作用研究进展  

Research advances on interleukin-6 in hypertrophic scar formation

作　　者：陈祖涵 余斌 叶啟发[1] 王彦峰[1] Chen Zuhan;Yu Bin;Ye Qifa;Wang Yanfeng(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,China)

机构地区：[1]武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植中心,移植医学技术湖北省重点实验室,武汉430071

出　　处：《中华烧伤与创面修复杂志》2022年第9期874-877,共4页Chinese Journal of Burns And Wounds

基　　金：武汉大学中南医院科技创新培育基金(znpy2019083)。

摘　　要：增生性瘢痕是受损皮肤的细胞外基质过度堆积导致的病理性修复结果,不同程度地影响患者的外观和功能。瘢痕形成的程度与创面愈合过程中炎症反应的强弱直接相关,过度或延长的炎症反应会增加增生性瘢痕的发生率。白细胞介素6(IL-6)是一种多效性细胞因子,可参与调控由成纤维细胞、巨噬细胞、角质形成细胞和血管内皮细胞组成的促纤维化网络,与增生性瘢痕的形成密切相关。该文就IL-6及其信号通路在增生性瘢痕形成中的作用进行综述。Hypertrophic scar is a pathological repair result of excessive accumulation of extracellular matrix after skin damage,which affects the appearance and function of patients with varying degrees.The degree of scar formation is directly related to the strength of inflammatory reaction during wound healing,and excessive or prolonged inflammatory response increases the incidence of hypertrophic scars.Interleukin-6(IL-6)is a pleiotropic cytokine that is involved in regulating the fibrotic network composed of fibroblasts,macrophages,keratinocytes,and vascular endothelial cells,and is closely related to the formation of hypertrophic scars.This article reviews the role of IL-6 and its signaling pathway in hypertrophic scar formation.

关 键 词：白细胞介素6 炎症 纤维化 皮肤 增生性瘢痕 

分 类 号：R622[医药卫生—整形外科]