维生素D与原发性甲状旁腺功能亢进症  

The vitamin D and primary hyperparathyroidism

作　　者：肖瑾恒 胡亚[1] XIAO Jinheng;HU Ya(Department of General Surgr,Peking Union Medical Cllge Hospilal Chinese Academy of Medicine Sciences&Peking Urion Medical College,Beijing 100730,P.R.China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院基本外科,北京100730

出　　处：《中国普外基础与临床杂志》2022年第9期1246-1249,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：中国医学科学院临床与转化医学研究基金(项目编号:2020-I2M-C&T-B-029)。

摘　　要：目的概述原发性甲状旁腺功能亢进症患者血清维生素D水平的变化及其与临床表现之间的关系,总结可能的致病机制。方法检索近年来与维生素D及原发性甲状旁腺功能亢进症相关的文献进行综述。结果原发性甲状旁腺功能亢进症患者存在不同程度的维生素D水平下降。维生素D水平与甲状旁腺腺瘤重量、甲状旁腺素水平及血钙水平呈负相关,与患者骨密度呈正相关。结论维生素D营养状态影响原发性甲状旁腺功能亢进症患者的疾病严重程度、主要生化指标及临床并发症。引起维生素D水平下降的原因多样,具体致病机制有待进一步研究。对于原发性甲状旁腺功能亢进症患者,在手术前可谨慎适当补充维生素D。Objective To summarize the changes of serum vitamin D level in patients with primary hyperparathyroidism(pHPT),the correlation between vitamin D and clinical manifestations,and feasible pathogenesis of pHPT.Method The literatures related to vitamin D and pHPT in recent years were reviewed.Results The level of vitamin D was decreased in patients with pHPT.Vitamin D level was negatively correlated with the weight of parathyroid adenoma,parathyroid hormone and blood calcium level,and positively correlated with bone mineral density.Conclusions Vitamin D nutritional status affects the severity of symptoms,main biochemical indexes and main clinical complications of patients with pHPT.There are various reasons accounted for the decline of vitamin D level,and the specific pathogenesis needs to be further explored.For patients with pHPT,vitamin D should be supplemented carefully and appropriately before surgical operation.

关 键 词：原发性甲状旁腺功能亢进症 维生素D 诊断 治疗 

分 类 号：R582.1[医药卫生—内分泌]