职业紧张和AGT基因对高血压患病率的影响  

Effects of occupational stress and AGT gene on the prevalence of hypertension

作　　者：付爱玲[1,2] 李雪 雍娴婷[1] 刘继文[1] FU Ai-ling;LI Xue;YONG Xian-ting;LIU Ji-wen(School of Public Health,Xinjiang Medical University,Urumqi,Xinjiang 830011,China)

机构地区：[1]新疆医科大学公共卫生学院,新疆乌鲁木齐830011 [2]新疆医科大学附属肿瘤医院病案管理科

出　　处：《现代预防医学》2022年第18期3288-3293,共6页Modern Preventive Medicine

基　　金：国家自然科学基金(81460489);新疆维吾尔自治区自然科学基金(2020D01C177)。

摘　　要：目的探讨职业紧张和AGT M235T和T174M位点多态性对新疆油田工人高血压患病率的影响。方法采用随机整群抽样方法抽取克拉玛依5个油田作业分公司的1200名工人并分发问卷,回收有效问卷1156份(有效率为96.33%)。运用聚合酶链式反应限制性片段长度多态性(PCR-RFLP)技术检测高血压病例组和对照组(各153例)AGT M235T和T174M位点的基因型。结果油田工人中男性、年龄<45岁,工龄≤15年、轮班作业、大专及以上文化程度、未婚、吸烟和饮酒组的职业紧张程度较高(P<0.05),且高血压患病率随着职业紧张程度的增加而升高(χ^(2)=16.959,P<0.001);病例组的AGT M235T位点TT基因型较多(P<0.05);T174M位点的基因型在病例组和对照组的差异无统计学意义(P>0.05)。二元logistic回归结果显示M235T位点的的MM、MT基因型和个体紧张反应是高血压的保护因素,TT基因型和高度职业紧张程度是其危险因素。结论AGT M235T位点的TT基因型、较高职业紧张和较低的个体紧张反应会增加高血压的发病风险;AGT T174M位点与本研究人群的高血压无关。Objective To investigate the effects of occupational stress and AGT M235T and T174M polymorphisms on the prevalence of hypertension in Xinjiang oilfield workers.Methods A random cluster sampling method was used to select 1200 workers from 5 oilfield operating branches in Karamay,and their occupational stress were investigated by occupational stress measurement questionnaire.In total 1156 valid questionnaires were collected,and the effective rate of the questionnaire was 96.33%.The genotypes of AGT gene M235T and T174M in the hypertensive case group and control group(153 cases in each)were detected by polymerase chain reaction-restriction fragment length polymorphism.Results Among the oilfield workers,the occupational stress degree of male,age<45 years old,working age≤15 years,shift workers,college education level or above,unmarried,smoking and drinking group was higher than that of other corresponding groups(P<0.05).The prevalence of hypertension in oilfield workers increased with the increase of occupational stress(χ^(2)=16.959,P<0.001).There were statistically significant differences in MM,MT and TT genotypes of AGT M235T between the case group and the control group(P<0.05),and there were more TT genotypes in the case group.There was no significant difference in the genotype of the T174M between the case group and the control group(P>0.05).The results of binary Logistic regression showed that the MM and MT genotypes of M235T and individual stress response were protective factors for hypertension,while the TT genotype and high occupational stress were risk factors for hypertension.Conclusion The TT genotype of AGT M235T,higher occupational stress and lower individual stress response increase the risk of hypertension.AGT T174M is not associated with hypertension.

关 键 词：职业紧张 AGT基因 高血压 

分 类 号：R544.1[医药卫生—心血管疾病] R135[医药卫生—内科学]