康复训练对脑胶质瘤患者脑组织中基质金属蛋白酶2蛋白表达的影响  

Effect of Rehabilitation Training on Expression of Matrix Metalloproteinase-2 Protein in Brain Tissue of Glioma Patients

作　　者：周保丹 李君 高飞[1] 乔卿均[1] 董辉 Zhou Bao-dan;LI Jun;Gao Fei;QIAO Qing-jun;DONG Hui(Department of Neurosurgery,Nanyang Second People's Hospital,Nanyang 473000,Henan Province,China;Department of Neurology,The First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan Province,China)

机构地区：[1]河南省南阳市第二人民医院神经外科,河南南阳473000 [2]南阳医学高等专科学校第一附属医院神经内科,河南南阳473000

出　　处：《罕少疾病杂志》2022年第10期31-32,共2页Journal of Rare and Uncommon Diseases

基　　金：河南省医学科技攻关计划项目(LHGJ20191471)

摘　　要：目的探究康复训练对脑胶质瘤患者脑组织中基质金属蛋白酶2(MMP2)蛋白表达的影响。方法选取2019年1月至2020年12月在我院诊断为脑胶质瘤患者100例,将患者分为对照组50例和观察组50例。对照组采取手术治疗,观察组在手术治疗的基础上采取康复训练,治疗周期为1个月,检测MMP2的含量,比较两组患者脑组织中MMP2蛋白的表达、运动及语言功能得分。结果观察组患者MMP2明显低于对照组,而运动和语言功能评分明显高于对照组(P<0.05)。结论康复训练能够降低脑胶质瘤患者脑组织中MMP2蛋白表达水平,提高运动和语言功能,促进脑组织的恢复。Objective To explore the effect of rehabilitation training on the expression of matrix metalloproteinase 2(MMP2)protein in brain tissue of glioma patients.Methods 100 patients with glioma diagnosed in our hospital from January 2019 to December 2020 were selected.The patients were divided into 50 cases in the control group and 50 cases in the observation group.The control group received surgical treatment,and the observation group received rehabilitation training on the basis of surgical treatment.The treatment cycle was 1 month.The content of MMP2 was detected,and the expression of MMP2 protein in brain tissue,motor and language function scores were compared between the two groups.Results MMP2 in the observation group was significantly lower than that in the control group,while the scores of motor and language function in the observation group were significantly higher than those in the control group(P<0.05).Conclusion Rehabilitation training can reduce the expression level of MMP2 protein in brain tissue of glioma patients,improve the motor and language function,and promote the recovery of brain tissue.

关 键 词：康复训练 脑胶质瘤 金属蛋白酶2 

分 类 号：R651[医药卫生—外科学]