蚁利肝胶囊联合替诺福韦对乙肝肝硬化患者的肝功能及病毒学指标的影响  

Effect of Formi Liver Capsule Combined with Tenofovir on Liver Function and Virological Index in Patients with Hepatitis B Cirrhosis

作　　者：范燕峰 FAN Yan-feng(Department of Internal Medicine 1,Jiaozuo Third People's Hospital,Jiaozuo 454172,Henan Province,China)

机构地区：[1]焦作市第三人民医院内一科,河南焦作454172

出　　处：《罕少疾病杂志》2022年第10期57-59,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的研究探讨蚁利肝胶囊联合替诺福韦对乙肝肝硬化患者的治疗效果及肝功能、病毒学指标的影响。方法选取2019年9月至2021年8月本院收治的98例乙肝肝硬化患者为治疗对象,随机抽签法分为观察组、对照组,各49例。对照组以替诺福韦治疗,观察组联合蚁利肝胶囊治疗。对两组患者的临床疗效、肝功能指标、病毒学指标、治疗安全性进行统计比较。结果观察组总有效率为91.84%(45/49),高于对照组患者为73.47%(36/49)(P<0.05)。治疗后观察组GGT、ALP、STB均低于对照组(P<0.05)。治疗后观察组患者的HBV-DNA、HBeAg、HBeAb水平均低于对照组(P<0.05)。治疗期间观察组、对照组不良反应发生率分别为14.29%(7/49)、10.20%(5/49)(P>0.05)。结论蚁利肝胶囊联合替诺福韦对乙肝肝硬化患者的治疗效果显著,能够改善患者的肝功能指标,降低患者的乙肝病毒学水平,治疗安全性良好,可临床推荐。Objective To study the therapeutic effect of liver capsule and tenofovir combined with tenofovir on patients with hepatitis B cirrhosis and the influence of liver function and virological index.Methods 98 patients with hepatitis B cirrhosis were randomly divided into observation group(49 cases)and control group(2019.09 to 2021.08).The control group was treated with tenofovir and the observation group was treated with yiligan capsule.The clinical efficacy,liver function index,virological index and treatment safety of the two groups were statistically compared.Results The observation group total effective rate was 91.84%(45/49),higher than control group 73.47%(36/49)(P<0.05).After treatment,the observation group levels of glutamyltransferase(GGT),alkaline phosphatase(ALP)and total bilirubin(STB)were lower than control group(P<0.05).After treatment,the observation group levels of HBV-DNA,HBeAg and HBeAb were lower than control group(P<0.05).The incidence of adverse reactions in the observation,control group were 14.29%(7/49)and 10.20%(5/49)respectively(P>0.05).Conclusion The therapeutic effect of formi liver capsule combined with tenofovir on patients with hepatitis B cirrhosis is remarkable.It can improve the liver function index and reduce the level of hepatitis B virus in patients.The treatment is safe and can be recommended clinically.

关 键 词：乙肝肝硬化 替诺福韦 蚁利肝胶囊 肝功能 病毒学指标 

分 类 号：R657.31[医药卫生—外科学]