面向新冠肺炎疫情防控需求的应用基础研究  

Applied Basic Research to Meet the Needs of COVID-19 Pandemic Prevention and Control

作　　者：袁伦志 张天英 张军[1,2] 夏宁邵[1,2] Lunzhi Yuan;Tianying Zhang;Jun Zhang;Ningshao Xia(State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics,Xiamen University,Xiamen 361102;National Institute of Diagnostics and VaccineDevelopment in Infectious Diseases,Xiamen University,Xiamen 361102)

机构地区：[1]厦门大学分子疫苗学和分子诊断学国家重点实验室,厦门361102 [2]厦门大学国家传染病诊断试剂与疫苗工程技术研究中心,厦门361102

出　　处：《中国科学基金》2022年第4期615-623,共9页Bulletin of National Natural Science Foundation of China

基　　金：国家自然科学基金项目(81991491)的资助。

摘　　要：严重急性呼吸综合征冠状病毒2(Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2)全球大流行导致的新冠肺炎疫情仍在持续,不断进化的变异毒株谱系具有较强的免疫逃逸和突破性感染能力,一系列新冠肺炎后遗症陆续被发现,并可能在未来对人类社会造成严重的医疗负担。我国面临“外防输入、内防反弹”的巨大抗疫压力,不仅需要全面统筹疫情防控和经济社会发展,还需要积极为将来全面放开出入境限制做好科技储备。建立完备的疫情防控体系和群体免疫屏障,研究和发展抗疫产品和科学技术,进一步减少重症和死亡,是保障人民生命健康、打赢抗疫“拉锯战”的法宝。厦门大学国家传染病诊断试剂与疫苗工程技术研究中心团队长期以来在国家自然科学基金项目的支持下,形成了坚实的感染性疾病研究积累,建立了系统的生物医药研究平台,锻造了一支朝气蓬勃的科研创新团队;面对复杂的疫情发展态势,围绕“诊断、预防、治疗”三方面的防控产品需求,在SARS-CoV-2检测技术体系、鼻喷流感病毒载体新冠疫苗和重组蛋白新冠疫苗、广谱中和抗体与小分子药物筛选、重症肺炎动物模型和致病机制等方面取得了一系列研究进展,为我国疫情防控和公共卫生事业提供了重要的科技支撑。Coronavirus disease 2019(COVID-19) pandemic caused by the spreading of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) is still ongoing. The evolving mutant strain lineage has strong immune escape and breakthrough infection capabilities. A series of COVID-19 sequelae have been discovered, and may cause a serious medical burden to human society in the future. Our country is still facing the tough battle of “external defense import and internal defense rebound ”, it is not only necessary to comprehensively coordinate epidemic prevention and control and economic and social development, but also to actively prepare scientific and technological reserves. Establishing a strong epidemic prevention and control system and herd immunity barrier, developing products and technologies that can be used to prevent and control the epidemic, and further reducing severe illness and death are the magic weapons to protect people’s lives and health and win the “tug-of-war” against the pandemic. With the continuous support of the National Natural Science Foundation of China, the team of the National Institute of Diagnostics and Vaccine Development in Infectious Diseases(Xiamen University) has formed a solid accumulation in the field of infectious disease research, established a systematic biomedical research platform, and cultivated a team of scientists full of innovation and vitality. In the face of the complex situation of the COVID-19 pandemic, we focus on the research and development of the product for “diagnosis, prevention and treatment”. A series of research progress has been made in SARS-CoV-2 detection technology, intranasal spray influenza virus vector COVID-19 vaccine and recombinant protein COVID-19 vaccine, broad-spectrum neutralizing antibody and small molecule drug screening, severe COVID-19 animal model and pathogenic mechanism, etc. These achievements have provided important scientific and technological support for prevention and control of COVID-19 and also contribute to public health.

关 键 词：新冠病毒 新冠肺炎 诊断 创新疫苗 治疗性抗体 动物模型 高通量药物筛选 

分 类 号：R563.1[医药卫生—呼吸系统] R184[医药卫生—内科学]