Toxicity of manufactured nanomaterials  

作　　者：Yaping Liu Shuang Zhu Zhanjun Gu Chunying Chen Yuliang Zhao 

机构地区：[1]CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience,National Center for Nanoscience and Technology of China and Institute of High Energy Physics,Beijing 100190,China [2]The First Affiliated Hospital of University of Science and Technology of China,Division of Life Sciences and Medicine,University of Science and Technology of China,Hefei 230001,China [3]College of Materials Science and Optoelectronic Technology,University of Chinese Academy of Sciences,Beijing 100049,China [4]GBA Research Innovation Institute for Nanotechnology,Guangzhou 510700,China

出　　处：《Particuology》2022年第10期31-48,共18页颗粒学报（英文版）

基　　金：supported by the Strategic Priority Research Program of Chinese Academy of Sciences(grant No.XDB36000000);the National Basic Research Program of China(grant No.2020YFA0710702);the National Natural Science Foundation of China(grant Nos.51822207 and 51772292).

摘　　要：Manufactured nanomaterials with unique properties have been extensively applied in various indus-trial,agricultural or medical fields.However,some of the properties have been identified to be closely related to nanomaterial toxicity.The"nano-paradox"has aroused concerns over the use and develop-ment of nanotechnology,which makes it difficult for regulatory agencies to regulate nanomaterials.The key to fulfilling proper nanomaterial regulation lies in the adequate understanding of the impact of nanomaterial properties on nano-bio interactions.To this end,we start the present work with a brief intro-duction to nano-bio interactions at different levels.Based on that,how key toxicity-associated properties of manufactured nanomaterials(i.e.,size,shape,chemical composition,surface properties,biocorona formation,agglomeration and/or aggregation state,and biodegradability)impact their toxicokinetics,cel-lular uptake,trafficking and responses,and toxicity mechanisms is deeply explored.Moreover,advanced analytical methods for studying nano-bio interactions are introduced.Furthermore,the current reg-ulatory and legislative frameworks for nanomaterial-containing products in different regions and/or countries are presented.Finally,we propose several challenges facing the nanotoxicology field and their possible solutions to shed light on the safety evaluation of nanomaterials.

关 键 词：Manufactured nanomaterial NANOTOXICITY Nano-bio interaction Nanomaterial property Analytical method REGULATION 

分 类 号：TB383[一般工业技术—材料科学与工程]