三酰甘油血糖指数用于预测高血压合并糖尿病患者下肢动脉硬化的研究  

The Study of Triglyceride Glucose Index for Predicting LowerExtremity Arteriosclerosis in Patients with HypertensionComplicated with Diabetes Mellitus

作　　者：梁蒙[1] 陈伟国 王新玲[2] LIANG Meng;CHEN Weiguo;WANG Xinling(Department of Cardiovascular Medicine,The Second Affiliated Hospital of Xi’an Medical College,Xi’an 710038,China;Department of Endocrinology,The People’s Hospital of Xinjiang Uygur Autonomous Region,Urumchi 830001,China)

机构地区：[1]西安医学院第二附属医院心血管内科,陕西西安710038 [2]新疆维吾尔自治区人民医院内分泌科,新疆乌鲁木齐830001

出　　处：《标记免疫分析与临床》2022年第8期1297-1302,共6页Labeled Immunoassays and Clinical Medicine

基　　金：陕西省卫生健康委员会基金资助项目(编号:2021E023);陕西省自然科学基础研究计划基金资助项目(编号:2021JQ-787)。

摘　　要：目的探讨三酰甘油血糖(triglyceride glucose,TyG)指数对高血压合并2型糖尿病患者发生下肢动硬化的预测作用。方法选取高血压合并2型糖尿病患者262例。按TyG指数将研究对象分为低TyG指数组、中TyG指数组和高TyG指数组。按踝肱指数(ankle brachial index,ABI)将研究对象分为下肢动脉硬化组、非下肢动脉硬化组。采用Logistic回归模型分析TyG指数与下肢动脉硬化发生的相关性。采用ROC曲线评估TyG指数对发生下肢动脉硬化的预测作用。结果随着TyG指数增高,高血压、高血糖、高血脂的比率随之增高。下肢动脉硬化组的血压、血糖、血脂均高于非下肢动脉硬化组。Logistic回归分析提示TyG指数是下肢动脉硬化发生的独立危险因素。ROC曲线分析提示当TyG指数截断取值为8.14时,其预测下肢动脉硬化发生的灵敏度为42.5%,特异性为83.3%。结论在高血压合并2型糖尿病患者中,TyG指数越高,发生下肢动脉硬化的风险越高,TyG指数可作为下肢动脉硬化发生的预测指标。Objective To investigate the predictive effect of triglyceride glucose(TyG)index on lower limb dynamic sclerosis in patients with hypertension complicated with type 2 diabetes mellitus.Methods 262 patients with hypertension complicated with type 2 diabetes mellitus were selected for the study.According to TyG index,these subjects were divided into the low TyG index group,medium TyG index group and high TyG index group.According to ankle-brachial index,these subjects were divided into the lower extremity atherosclerosis group and non-lower extremity atherosclerosis group.Logistic regression model was applied to analyze the correlation between TyG index and lower limb arteriosclerosis.The predictive effect of TyG index on lower limb arteriosclerosis was evaluated by ROC curve.Results With the increase of TyG index,the rates of hypertension,hyperglycemia and hyperlipidemia increased.Blood pressure,blood glucose and blood lipid of the lower limb arteriosclerosis group were higher than those of the non-lower limb arteriosclerosis group.Logistic regression analysis suggested that TyG index was an independent risk factor for lower extremity arteriosclerosis.ROC curve analysis indicated that when TyG index truncation value was 8.14,the sensitivity and specificity of TyG index for predicting the occurrence of lower limb atherosclerosis were 42.5%and 83.3%,respectively.Conclusion In patients with hypertension complicated with type 2 diabetes,the higher TyG index,the higher the risk of lower extremity atherosclerosis,suggesting that TyG index can be used as a predictor of lower extremity atherosclerosis.

关 键 词：三酰甘油血糖指数 高血压 糖尿病 下肢动脉硬化 胰岛素抵抗 

分 类 号：R446.1[医药卫生—诊断学]