组学技术在心房颤动中的研究进展  

Omics Technology in Atrial Fibrillation

作　　者：梁士楚 马敏[1] 赵韧[2] 贺勇[1] LIANG Shichu;MA Min;ZHAO Ren;HE Yong(Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China;Department of Cardiology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,Anhui,China)

机构地区：[1]四川大学华西医院心脏内科,四川成都610041 [2]安徽医科大学第一附属医院心血管内科,安徽合肥230022

出　　处：《心血管病学进展》2022年第9期774-777,共4页Advances in Cardiovascular Diseases

基　　金：中国博士后科学基金第68批面上资助项目(2020M683325);四川省科技厅应用基础重点项目(2017JY0026);四川大学华西医院专职博士后研发基金(2020HXBH048);2020年四川省医学(青年创新)科研课题(Q20061)。

摘　　要：心房颤动(房颤)是最常见的心律失常之一,因其发病率高、并发症多和发病机制复杂备受关注。随着精准医疗的发展,个体化治疗的理念愈发受到重视,寻求新的生物标志物在房颤诊疗中显得尤为重要。组学可从单个样本中生成复杂的高维数据,进而描述某个生物分子的详细特征,多组学联合分析有助于推动房颤机制及致病靶点的研究,为疾病诊疗提供理论支持及技术基础。现就基因组学、转录组学、蛋白质组学、代谢组学及影像组学方面对组学技术在房颤中的研究应用做一综述。Atrial fibrillation is one of the most common arrhythmias, which has attracted much attention due to its high incidence rate, many complications and complex pathogenesis.With the development of precision medicine, the concept of individualized treatment has been paid more and more attention.It is of vital significance to seek new biomarkers in the diagnosis and treatment of atrial fibrillation.Omics generates complex high-dimensional data from a single sample to describe the detailed characteristics of a biomolecule.The combined analysis of multi-omics is helpful to promote the research on the mechanism and pathogenic target of atrial fibrillation, and provide theoretical support and technical basis for disease diagnosis and treatment.This paper reviews the application of genomics, transcriptomics, proteomics, metabolomics and radiomics in atrial fibrillation.

关 键 词：心房颤动 组学 精准医疗 

分 类 号：R541.75[医药卫生—心血管疾病]