喜炎平注射液治疗手足口病人群的联合用药方案复杂网络分析  

Complex network analysis of combined regimens of Xiyanping injection in the treatment of hand-foot-mouth disease

作　　者：杜莹 王志飞[1] 谢雁鸣[1] 王连心[1] 李利寻 刘志帅 DU Ying;WANG Zhifei#;XIE Yanming;WANG Lianxin;LI Lixun;LIU Zhishuai(Institute of Basic Clinical Medicine of Traditional Chinese Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;School of Statistics,Renmin University of China,Beijing 100872,China)

机构地区：[1]中国中医科学院中医临床基础医学研究所,北京100700 [2]中国人民大学统计学院,北京100872

出　　处：《中国药物警戒》2022年第8期839-844,共6页Chinese Journal of Pharmacovigilance

基　　金：国家自然科学基金资助项目(81973982);国家重点研发计划(2018YFC1707410)。

摘　　要：目的获得喜炎平注射液在真实世界中治疗手足口病人群的联合用药方案。方法收集2006年12月1日至2016年6月30日全国28家三甲医院HIS系统的病例,着重针对喜炎平注射液治疗手足口病的人群进行分析,采用Tabu搜索算法,对真实世界研究中庞大但质量较高的数据进行复杂网络建模。结果共获得19999名患者联合用药信息数据,构建核心联用西药类别用药子结构群,频次第1位为喜炎平注射液+维生素类,第2位为喜炎平注射液+干扰素类,第3位为喜炎平注射液+免疫增强剂;核心联用中药用类别药频次第1位为喜炎平注射液+清热剂,第2位为喜炎平注射液+开窍剂,第3位为喜炎平注射液+清热解毒剂。结论喜炎平注射液联合用药可用于治疗手足口病轻、重症患者,为临床治疗提供参考。Objective To obtain the combined medication schemes of Xiyanping injection in the treatment of handfoot-mouth disease in the real world.Methods The clinical data on patients with hand-foot-mouth disease treated by Xiyanping injection between December 1,2006 and June 30,2016 was collected from 28 large hospitals in China and analyzed with the Tabu search algorithm.Complex network modeling of large but high-quality data in the real-world research was attempted.Results The data on combined medications of a total of 19999 patients was harvested.Based on the sub structure group of categories of core combinations with western medicine,the most frequently used combination was Xiyanping injection+vitamins,followed by Xiyanping injection+interferons and Xiyanping injection+immune enhancers.The most frequently used core combination with traditional Chinese medicine was Xiyanping injection+antipyretics,followed by Xiyanping injection+formula for resuscitation and Xiyanping injection+antipyretics or antidotes.Conclusion Xiyanping injection is often used in combination with other drugs in the treatment of mild and severe hand-foot-and mouth disease.

关 键 词：喜炎平注射液 手足口病 联合用药 复杂网络 TABU搜索算法 真实世界 

分 类 号：R969[医药卫生—药理学]