中成药降低肉芽肿性小叶性乳腺炎恢复期复发率的临床疗效对比  

Comparison of Clinical Efficacy of Chinese Patent Medicines in Reducing Recurrence Rate of GLM during Convalescence

作　　者：李斐斐 史有阳 杨小娟 孙霃平[1] 刘胜[1] LI Feifei;SHI Youyang;YANG Xiaojuan;SUN Chenping;LIU Sheng(Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200030,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200030

出　　处：《中医药学报》2022年第10期66-70,共5页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金面上项目(81774308);上海市进一步加快中医药事业发展三年行动计划(ZY[2018-2020]-ZYBZ-01)。

摘　　要：目的:观察乳癖散结胶囊及红金消结胶囊在肉芽肿性小叶性乳腺炎(GLM)恢复期降低复发率的疗效。方法:本研究为回顾性队列研究,共纳入GLM恢复期服用乳癖散结胶囊或红金消结胶囊的GLM患者173例,其中乳癖散结组129例,红金消结组44例。根据患者服用中成药的治疗时间,分别将其分为2周~6个月及≥6个月两个亚组,比较各组患者复发率差异。结果:乳癖散结组患者复发率为6.98%(9/129),红金消结组患者复发率为9.09%(4/44),两组患者复发率比较无明显差异(P=0.087)。各组间亚组比较显示,乳癖散结组及红金消结组两组间在2周~6个月及≥6个月两个亚组均无显著性差异(P=0.135,P=0.670)。乳癖散结组内亚组比较,与2周~6个月患者人群相比,≥6个月GLM患者复发率明显降低,差异具有统计学意义(P=0.001);红金消结组内两亚组比较,复发率无明显差异(P=0.139)。结论:在GLM恢复期,乳癖散结胶囊及红金消结胶囊均为有效的降低复发率治疗方案。Objective: To observe the efficacy of Rupi Sanjie Capsule and Hongjin Xiaojie Capsule in reducing the recurrence rate of granulomatous lobular mastitis( GLM) during convalescence. Methods: This study was a retrospective cohort study. A total of 173 GLM patients who took Rupi Sanjie Capsule or Hongjin Xiaojie Capsule during the recovery period of GLM were enrolled,including 129 cases in the Rupi Sanjie group and 44 cases in the Hongjin Xiaojie group.According to the medication time,they were divided into two subgroups of 2 weeks to 6 months and more than 6 months,and the differences in the recurrence rate were compared in each group. Results: The recurrence rate was 6. 98%( 9/129) in the Rupi Sanjie group and 9. 09%( 4/44) in the Hongjin Xiaojie group;there was no significant difference in the recurrence rate between the two groups( P = 0. 087). The comparison of the subgroups showed that there were no significant differences between the two subgroups both in the Rupi Sanjie group and the Hongjin Xiaojie group( P =0. 135,P = 0. 670). In the Rupi Sanjie group,the recurrence rate of the patients with GLM more than 6 months was significantly lower than that of the patients with GLM from 2 weeks to 6 months,and the difference was statistically significant( P = 0. 001);within the Hongjin Xiaojie group,there was no significant difference in the recurrence rate between the two subgroups( P = 0. 139). Conclusion: During the recovery period of GLM,Rupi Sanjie Capsule and Hongjin Xiaojie Capsule are both effective treatment options for reducing the recurrence rate.

关 键 词：肉芽肿性小叶性乳腺炎 恢复期 乳癖散结胶囊 红金消结胶囊 复发率 

分 类 号：R271.44[医药卫生—中医妇科学]