肺表面活性物质联合NCPAP治疗新生儿呼吸窘迫综合征的效果观察  

Effectiveness of pulmonary surfactant combined with NCPAP in the treatment of neonatal respiratory distress syndrome

作　　者：廖春玲[1] 王立强[1] LIAO Chunling;WANG Liqiang(Department of Neonatology,the Second People’s Hospital of Nanyang City,Nanyang 473000,China)

机构地区：[1]南阳市第二人民医院新生儿科,南阳473000

出　　处：《上海医药》2022年第19期20-22,27,共4页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:探讨肺表面活性物质(PS)联合鼻塞式持续气道正压通气(NCPAP)治疗新生儿呼吸窘迫综合征的临床效果。方法:将180例呼吸窘迫综合征患儿根据就诊号奇偶数将受试者分为对照组(n=90)和研究组(n=90),对照组患儿仅接受NCPAP治疗,研究组患儿在对照组的基础上联合PS治疗,比较两组患儿治疗效果及治疗前后各血气指标变化。结果:研究组患者总有效率高于对照组,症状缓解时间、机械通气时间、住院时间少于对照组,并发症发生率低于对照组,血气指标优于对照组(均P <0.05)。结论:PS联合NCPAP可有效改善患儿血气指标,减少并发症,缩短治疗时间,对改善新生儿呼吸窘迫综合征预后具有积极意义。Objective:To investigate the clinical effects of pulmonary surfactant(PS) combined with nasal continuous positive airway pressure(NCPAP) in the treatment of neonatal respiratory distress syndrome.Methods:One hundred and eighty children with respiratory distress syndrome were divided into a control group(n=90) and a study group(n=90) according to the odd and even number of consultation numbers,and the children in the control group only received NCPAP treatment,while the children in the study group were treated with PS in addition to the control group.Results:The total effective rate was higher,the time for symptom relief,mechanical ventilation and hospitalization was less,the incidence of complication was lower and the blood gas index was better in the study group than the control group(all P<0.05).Conclusion:PS combined with NCPAP can effectively improve the blood gas index,reduce complications and shorten the treatment time,which has positive significance in the improvement of the prognosis of neonatal respiratory distress syndrome.

关 键 词：PS NCPAP 新生儿 呼吸窘迫综合征 

分 类 号：R974[医药卫生—药品] R722.19[医药卫生—药学]