九价人乳头瘤病毒疫苗接种后抗体阳转率的meta分析  

A meta-analysis of antibody positive rate after nine-valent HPV vaccination

作　　者：章承锋[1] 董永海[1] 刘芸[2] 杨柽 ZHANG Chengfeng;DONG Yonghai;LIU Yun;YANG Cheng(Emergency Transmission Center,Jiangxi Provincial Center for Disease Control and Prevention,Jiangxi Province,Nanchang 330029,China;Department of Imaging,Jiangxi Provincial People′s Hospital,Jiangxi Province,Nanchang 330006,China)

机构地区：[1]江西省疾病预防控制中心应急传防所,江西南昌330029 [2]江西省人民医院影像科,江西南昌330006

出　　处：《中国当代医药》2022年第27期10-14,共5页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(20204857)。

摘　　要：目的利用meta分析的方法探讨九价人乳头瘤病毒(HPV)疫苗接种后抗体阳转率情况。方法检索PubMed、Embase、中国知网、万方、维普数据库中有关接种九价HPV疫苗后与接种四价HPV疫苗在抗体阳转率方面的随机对照试验(RCT)研究。检索时间自建库至2021年11月。应用Stata 12.0软件进行meta分析。结果共纳入6项RCT研究。结果表明接种九价HPV与四价HPV疫苗7个月后,两种疫苗的抗HPV-6/11/16/18阳转率比较,差异无统计学意义(P>0.05);接种九价HPV疫苗后抗HPV-31/33/45/52/58阳转率均高于四价HPV疫苗,差异有统计学意义(抗HPV-31:RR=2.10,95%CI=1.86~2.36;抗HPV-33:RR=7.99,95%CI=7.01~9.11;抗HPV-45:RR=11.03,95%CI=9.21~13.20;抗HPV-52:RR=32.17,95%CI=26.51~39.05;抗HPV-58:RR=4.96,95%CI=3.91~6.28)。结论与四价HPV疫苗相比,九价HPV疫苗具有良好的免疫原性。Objective To investigate the rate of antibody positive conversion after 9-valent human papillomavirus(HPV)vaccination by meta-analysis.Methods Randomized controlled trials(RCT)were searched in PubMed,Embase,CNKI,Wanfang and VIP databases for the positive rate of antibody after vaccination with 9-valent HPV vaccine and with quadrivalent HPV vaccine until November 2021.Meta-analysis was performed using Stata 12.0 software.Results A total of 6 RCTs were included.The results showed that there was no statistically significant difference in anti-HPV-6/11/16/18 positive rate between 9-valent HPV vaccine and quadrivalent HPV vaccine after inoculation(P>0.05).The positive rates of anti-HPV-31/33/45/52/58 with nine-valent HPV vaccine were higher than those of quadrivalent HPV vaccine,and the differences were statistically significant(anti-HPV-31:RR=2.10,95%CI=1.86-2.36;anti-HPV-33:RR-7.99,95%CI=7.01-9.11;anti-HPV-45:RR=11.03,95%CI=9.21-13.20;anti-HPV-52:RR=32.17,95%CI=26.51-39.05;anti-HPV-58:RR=4.96,95%CI=3.91-6.28).Conclusion Compared with quadrivalent HPV vaccine,nine-valent HPV vaccine has good immunogenicity.

关 键 词：人乳头瘤病毒 随机对照试验 抗体阳转率 META分析 

分 类 号：R392[医药卫生—免疫学]