伊曲康唑与灰黄霉素治疗儿童头癣的疗效及安全性观察  

Efficacy and safety of Itraconazole and Griseofulvin in the treatment of tinea capitis in children

作　　者：涂盛安 刘灵花 周蜜 TU Sheng′an;LIU Linghua;ZHOU Mi(Department of Dermatology,Jiujiang Third People′s Hospital,Jiangxi Province,Jiujiang334000,China)

机构地区：[1]江西省九江市第三人民医院皮肤科,江西九江334000

出　　处：《中国当代医药》2022年第28期62-65,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(20204292)。

摘　　要：目的比较伊曲康唑与灰黄霉素治疗儿童头癣的疗效及安全性。方法选取2020年1月至2022年1月九江市第三人民医院及九江学院附属医院收治的70例头癣患儿作为研究对象,采用随机数字表法分为A组(35例,接受伊曲康唑治疗)与B组(35例,接受灰黄霉素治疗)。比较两组治疗第4、6、8周的临床疗效与真菌清除率,比较两组治疗前与治疗后10周的血清胱抑素C(Cys-C)、头癣症状改善时间、视黄醇结合蛋白(RBP)、不良反应及β2微球蛋白(β2-MG)水平。结果治疗后A组的RBP、Cys-C水平低于B组,差异有统计学意义(P<0.05)。治疗后两组的β2-MG水平比较,差异无统计学意义(P>0.05)。A组患儿的红斑、脱发、黄痂、脓疱改善时间短于B组,A组的不良反应总发生率低于B组,差异有统计学意义(P<0.05)。两组治疗第4、6、8周的真菌清除率与临床疗效总有效率比较,差异无统计学意义(P>0.05)。结论伊曲康唑治疗儿童头癣的临床疗效与灰黄霉素一致,但伊曲康唑可有效缩短头癣患儿临床症状改善时间,且具有更高的药物安全性。Objective To compare the efficacy and safety of Itraconazole and Griseofulvin in the treatment of tinea capitis in children.Methods From January 2020 to January 2022,a total of 70 children with tinea capitis who were admitted to Jiujiang Third People′s Hospital and Affiliated Hospital of Jiujiang University were selected as the research objects and divided into group A(35 cases,treated with Itraconazole)and group B(35 cases,treated with Griseofulvin)by random number table method.The clinical efficacy and fungal clearance rate of the two groups at the 4th,6th and 8th weeks of treatment were compared.The serum cystatin C(Cys-C),the improvement time of tinea capitis symptoms,retinol binding protein(RBP),adverse reactions andβ2 microglobulin(β2-MG)level of the two groups were compared.Results After treatment,the levels of RBP and Cys-C in group A were lower than those in group B,and the differences were statistically significant(P<0.05).There was no significant difference inβ2-MG level between the two groups after treatment(P>0.05).The improvement time of erythema,alopecia,yellow scab and pustule in group A were shorter than that in group B,and the total incidence of adverse reactions in group A was lower than that in group B,and the differences were statistically significant(P<0.05).There were no significant differences in the fungal clearance rate and the total effective rate of clinical efficacy at the 4th,6th and 8th weeks of treatment between the two groups(P>0.05).Conclusion The clinical efficacy of Itraconazole in the treatment of tinea capitis in children is consistent with Griseofulvin,but Itraconazole can effectively shorten the time for the improvement of clinical symptoms in children with lichen capitis and has higher drug safety.

关 键 词：头癣 伊曲康唑 真菌 灰黄霉素 药物安全性 

分 类 号：R751[医药卫生—皮肤病学与性病学]