呼吸道合胞病毒感染相关受体的研究进展  

An update on researches of the receptors for respiratory syncytial virus infection

作　　者：冯梓恒 许黎黎 Feng Ziheng;Xu Lili(National Center for Children’s Health,Beijing Children’s Hospital,Capital Medical University,Beijing Laboratory of Pediatric Infection Diseases and Viruses,Research Unit of Critical Infection in Children,Chinese Academy of Medical Sciences,National Clinical Research Center for Respiratory Diseases,Key Laboratory of Major Diseases in Children,Ministry of Education,Beijing Key Laboratory of Pediatric Respiratory Infection Diseases,Beijing 100045,China)

机构地区：[1]国家儿童医学中心首都医科大学附属北京儿童医院北京市儿科研究所感染与病毒研究室中国医学科学院儿童危重感染诊治创新单元国家呼吸系统疾病临床医学研究中心教育部儿科重大疾病研究重点实验室儿童呼吸道感染性疾病研究北京市重点实验室,北京100045

出　　处：《结核与肺部疾病杂志》2022年第5期411-415,共5页Journal of Tuberculosis and Lung Disease

基　　金：国家自然科学基金(82172275);中国医学科学院儿童危重感染诊治创新单元项目(2019-I2M-5-026)。

摘　　要：呼吸道合胞病毒(respiratory syncytial virus,RSV)是导致儿童和老年人下呼吸道感染的常见病原体之一。目前还没有疫苗可预防RSV感染,预防性和治疗性的RSV特异性抗体,由于其昂贵的价格和不确定的临床价值,主要在高危人群中使用。受体是病毒感染细胞一个决定性因素,它参与了病毒的入胞、致病等过程。因此,识别与RSV相互作用的受体,并研究其在RSV感染过程中的作用,对于深入了解RSV的致病过程并寻找治疗靶点有着非常重要的意义。笔者主要对已知的RSV感染所需受体及其致病机制进行综述,为未来RSV致病机制研究及潜在药物靶点和疫苗开发提供相关的信息。Respiratory syncytial virus(RSV)is a common cause of lower respiratory tract infections and responsible for a large proportion of mortality in children and the elderly.There are no licensed vaccines available to date.Prophylaxis and therapeutic RSV-specific antibodies are limited to populations at high risk owning to high cost and uncertain clinical value.Receptors and host factors are two determinants important for virus entry and establishment of infection in vivo.The identification and understanding of viral receptors and host factors can help us to gain insight into the pathogenesis of RSV infection.Herein,we reviewed receptors and host factors that have been reported thus far.We were characterized the functions and their roles in the life cycle of RSV,trying to provide an update on the information of RSV related receptors.

关 键 词：呼吸道合胞体病毒感染 受体 细胞因子 综述 

分 类 号：R373.1[医药卫生—病原生物学] G353.11[医药卫生—基础医学]