氨氯地平联合厄贝沙坦对高血压患者血清内皮细胞功能及炎症因子水平的影响?  

Effect of amlodipine combined with irbesartan on serum endothelial cell function and inflammatory factor level in patients with hypertension

作　　者：吴飞 刘海鹏 赵决奎 WU Fei;LIU Haipeng;ZHAO Juekui(Department of Cardiovascular Medicine,the Fourth People's Hospital,Tongling 244000,Anhui,China;Department of Pediatrics,Anhui Provincial Children's Hospital,Hefei 230051,Anhui,China)

机构地区：[1]铜陵市第四人民医院心血管内科,安徽铜陵244000 [2]安徽省儿童医院儿科,安徽合肥230051

出　　处：《贵州医科大学学报》2022年第9期1107-1111,1116,共6页Journal of Guizhou Medical University

基　　金：安徽省重点研究与开发计划项目(1704a0802177)。

摘　　要：目的探讨氨氯地平联合厄贝沙坦对高血压患者血清内皮细胞功能及炎症因子水平的影响。方法128例高血压患者随机分为对照组(厄贝沙坦口服)和观察组(氨氯地平+厄贝沙坦口服),均治疗8周;收集2组患者的一般临床资料(性别、年龄、病程及体质量指数)和住院期间的不良反应发生情况(皮疹、头晕及恶心呕吐),测量2组患者治疗前后的舒张压、收缩压水平并判断临床疗效;抽取2组患者治疗前后空腹静脉血,采用硝酸还原法检测血清中的一氧化氮(NO),采用放射免疫法检测内皮素-1(ET-1)水平,采用酶联免疫法法检测血清白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平。结果观察者患者的总有效率(96.88%)高于对照组(85.94%,P<0.05);治疗后2组患者的舒张压和收缩压均较治疗前下降,且观察组<对照组(P<0.05);治疗后2组患者的NO升高、ET-1降低,且观察组患者的NO高于对照组,ET-1水平低于对照组(P<0.05);治疗后2组患者的IL-6、TNF-α水平均较治疗前降低,且观察组<对照组(P<0.05);2组患者不良反应的发生率比较,差异无统计学意义(P>0.05)。结论氨氯地平联合厄贝沙坦可有效降低高血压患者的血压,其机制可能与两药联用保护心血管内皮功能、抑制炎症反应有关。Objective To investigate the effect of amlodipine combined with irbesartan on serum endothelial cell function and inflammatory factor level in patients with hypertension.Methods A total of 128 patients with hypertension were randomly divided into control group(oral administration of Irbesartan)and observation group(oral administration of amlodipine and irbesartan).All patients were treated for 8 weeks.The general clinical data(gender,age,course of disease and body mass index)and adverse reactions(rash,dizziness,nausea and vomiting)during hospitalization were collected in the two groups.The diastolic and systolic blood pressure levels of the two groups were measured before and after treatment and the clinical efficacy was judged;The fasting venous blood samples of the two groups were collected before and after treatment.Nitric oxide(NO)in the serum was detected by nitrate reduction test;endothelin-1(ET-1)was detected by radioimmunoassay(RIA);serum interleukin-6(IL-6)and tumor necrosis factor alpha(TNF-α)were detected by enzyme-linked immunosorbent assay(ELISA).Results The total effective rate of the observation group(96.88%)was higher than that of the control group(85.94%,P<0.05).After treatment,the diastolic and systolic blood pressure of the two groups decreased compared with that before treatment,and the observation group was less than that of the control group(P<0.05).After treatment,NO level increased and ET-1 decreased in the two groups,and No level in the observation group was higher than that in the control group while ET-1 level was lower than that in the control group(P<0.05).IL-6 and TNF-αin the two groups were lower than those before treatment,and the observation group was lower than the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Amlodipine,in combination of irbesartan,can effectively reduce blood pressure in patients with hypertension,and the mechanism may be related to the protection of cardiovascular end

关 键 词：氨氯地平 高血压 一氧化氮 白细胞介素6 肿瘤坏死因子Α 厄贝沙坦 内皮素?1 

分 类 号：R544.1[医药卫生—心血管疾病]