黄龙止咳颗粒联合常规西药治疗儿童反复呼吸道感染临床研究  

Clinical Study on Huanglong Zhike Granules Combined with Routine Western Medicine for Children with Recurrent Respiratory Tract Infection

作　　者：李冰冰 马春英[1] 彭献华[1] 郑卫星 李富 LI Bingbing;MA Chunying;PENG Xianhua;ZHENG Weixing;LI Fu

机构地区：[1]三门峡市中心医院普通儿科,河南三门峡472000

出　　处：《新中医》2022年第17期158-161,共4页New Chinese Medicine

摘　　要：目的:观察黄龙止咳颗粒联合常规西药治疗儿童反复呼吸道感染的疗效及对外周血T细胞亚群的影响。方法:选取100例反复呼吸道感染患儿,按随机数字表法分为对照组和研究组各50例。对照组采取西医常规治疗,研究组在对照组基础上联合黄龙止咳颗粒治疗。评价2组临床疗效及不良反应发生情况,比较2组症状消失时间以及治疗前后T细胞亚群水平。结果:研究组总有效率为96.00%,高于对照组88.00%,差异有统计学意义(P<0.05)。研究组退热时间、咳痰消失时间、喘息消失时间及肺部啰音消失时间均短于对照组,差异有统计学意义(P<0.05)。治疗前,2组T细胞亚群水平比较,差异无统计学意义(P>0.05)。治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平高于治疗前(P<0.05),且研究组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05);治疗后,2组CD8^(+)水平低于治疗前(P<0.05),且研究组CD8^(+)水平低于对照组(P<0.05)。结论:黄龙止咳颗粒联合常规西药治疗反复呼吸道感染患儿疗效及安全性均较高,可有效减轻患儿临床症状,显著改善其免疫功能。Objective:To observe the curative effect of Huanglong Zhike granules combined with routine western medicine for children with recurrent respiratory tract infection and its effect on T cel subsets in peripheral blood.Methods:A total of 100 cases of children with recurrent respiratory tract infection were selected and divided into the control group and the study group according to the random number table method,with 50 cases in each group.The control group was treated with routine western medicine,and the study group was additionally treated with Huanglong Zhike granules based on the treatment of the control group.The clinical effects and the incidence of adverse reactions in the two groups were evaluated;the levels of T cell subsets before and after treatment as well as the disappearance time of symptoms in the two groups were compared.Results:The total effective rate was 96.00%in the study group,higher than that of 88.00%in the control group,the difference being significant(P<0.05).The antipyretic time and the disappearance time of expectoration,wheezing and pulmonary rales in the study group were shorter than those in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of T cell subsets between the two groups(P>0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were higher than those before treatment(P<0.05),and the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the study group were higher than those in the control group(P<0.05).After treatment,the levels of CD8^(+)in the two groups were lower than those before treatment(P<0.05),and the level of CD8^(+)in the study group was lower than that in the control group(P<0.05).Conclusion:The therapy of Huanglong Zhike granules combined with routine western medicine for children with recurrent respiratory tract infection has a good curative effect and high safety,which can effectively relieve their clinical symptoms and significantl

关 键 词：反复呼吸道感染 儿童 黄龙止咳颗粒 T细胞亚群 不良反应 

分 类 号：R725.6[医药卫生—儿科]