苏黄止咳胶囊联合阿奇霉素治疗儿童支原体肺炎临床研究  

Clinical Study on Suhuang Zhike Capsules Combined with Azithromycin for Mycoplasma Pneumonia in Children

作　　者：苏莎莎[1] 齐晓宇 刘肖君[1] 尹锋 SU Shasha;QI Xiaoyu;LIU Xiaojun;YIN Feng

机构地区：[1]洛阳市中心医院药学部,河南洛阳471000

出　　处：《新中医》2022年第17期162-165,共4页New Chinese Medicine

摘　　要：目的:观察苏黄止咳胶囊联合阿奇霉素治疗儿童支原体肺炎的临床疗效。方法:选择98例支原体肺炎患儿为研究对象,按随机数字表法分为观察组和对照组各49例。2组均接受止咳、平喘及降温等对症处理。对照组采用阿奇霉素治疗,观察组在对照组基础上加用苏黄止咳胶囊治疗,2组均治疗10 d。比较2组临床疗效以及临床症状与体征消失时间,检测2组治疗前后降钙素原(PCT)和超敏C-反应蛋白(hs-CRP)水平,记录2组不良反应情况。结果:观察组总有效率为98.0%,高于对照组79.6%,差异有统计学意义(P<0.05)。治疗后,观察组湿啰音消失时间、喘憋消失时间、咳嗽消失时间和退热时间均低于对照组,差异有统计学意义(P<0.05)。治疗前,2组PCT及hs-CRP水平比较,差异无统计学意义(P>0.05)。治疗后,2组PCT及hs-CRP水平较治疗前降低,且观察组PCT及hs-CRP水平低于对照组,差异有统计学意义(P<0.05)。结论:苏黄止咳胶囊联合阿奇霉素治疗儿童支原体肺炎临床疗效较好,能显著改善患儿的临床症状,降低其炎性因子水平,安全性较高。Objective:To observe the clinical effect of Suhuang Zhike capsules combined with azithromycin for mycoplasma pneumonia in children.Methods:A total of 98 cases of children with mycoplasma pneumonia were selected as the research objects,and were divided into the observation group and the control group according to the random number table method,with 49 cases in each group.Both groups were given symptomatic treatment including relieving cough and asthma,and cooling;the control group was treated with azithromycin,and the observation group was additionally treated with Suhuang Zhike capsules based on the treatment of the control group.Both groups were treated for 10 days.The clinical effects and the disappearance time of clinical symptoms and signs in the two groups were compared.The levels of procalcitonin(PCT)and hypersensitive C-reactive protein(hs-CRP)before and after treatment in the two groups were detected,and the adverse reactions in the two groups were recorded.Results:The total effective rate was 98.0%in the observation group,higher than that of 79.6%in the control group,the difference being significant(P<0.05).After treatment,the disappearance time of moist rales,asthma,coughing and fever in the observation group were shorter than that in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the levels of PCT and hs-CRP between the two groups(P>0.05).After treatment,the levels of PCT and hs-CRP in the two groups were decreased when compared with those before treatment,and the levels of PCT and hs-CRP in observation group were lower than those in the control group,the difference being significant(P<0.05).Conclusion:The therapy of Suhuang Zhike capsules combined with azithromycin for mycoplasma pneumonia in children has a good clinical effect,and can significantly improve the clinical symptoms of children and reduce the levels of inflammatory factors,with high safety.

关 键 词：支原体肺炎 苏黄止咳胶囊 阿奇霉素 超敏C-反应蛋白 降钙素原 不良反应 

分 类 号：R725.6[医药卫生—儿科]