丹芍汤联合西咪替丁注射液治疗小儿皮肤型过敏性紫癜临床研究  

Clinical Study on Danshao Tang Combined with Cimetidine Injection for HenochSchtinlein Purpura of Cutaneous Type in Children

作　　者：陈虹宇[1] 姚奏英[1] 吴振波[1] 朱建央[1] CHEN Hongyu;YAO Zouying;WU Zhenbo;ZHU Jianyang

机构地区：[1]丽水市中心医院,浙江丽水323000

出　　处：《新中医》2022年第17期178-182,共5页New Chinese Medicine

基　　金：浙江省医学会临床科研资金项目(2019ZYC-A53)。

摘　　要：目的:观察丹芍汤联合西咪替丁注射液治疗小儿皮肤型过敏性紫癜(HSP)的疗效及对患儿免疫功能的影响。方法:选取68例皮肤型HSP患儿,按随机数字表法分为对照组及治疗组各34例。2组入院后均给予常规基础治疗,对照组给予西咪替丁注射液治疗,治疗组在对照组基础上给予丹芍汤治疗,2组均以10 d为1个疗程,共治疗2个疗程。比较2组临床疗效,比较2组治疗前后中医证候积分、免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))的变化,观察2组治疗后临床症状消失时间。结果:治疗后,治疗组临床疗效总有效率为94.12%,对照组为76.47%,2组比较,差异有统计学意义(P<0.05)。治疗后,2组中医证候积分均较治疗前下降,治疗组中医证候积分低于对照组,差异均有统计学意义(P<0.05)。治疗后,治疗组皮疹、瘙痒、皮肤疼痛消失时间均早于对照组,差异均有统计学意义(P<0.05)。治疗后,2组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均较治疗前升高,CD8^(+)水平均较治疗前下降,差异均有统计学意义(P<0.05);治疗后,治疗组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)水平均高于对照组,CD8^(+)水平低于对照组,差异均有统计学意义(P<0.05)。结论:对皮肤型HSP患儿给予丹芍汤联合西咪替丁注射液治疗,可提高临床疗效,促进患儿症状及体征改善,提高机体免疫功能。Objective:To observe the curative effect of Danshao tang combined with cimetidine injection for Henoch-Schtinlein purpura(HSP)of cutaneous type in children and its effect on immune function.Methods:A total of 68 cases of children with HSP of cutaneous type were selected and divided into the control group and the treatment group according to the random number table method,with 34 cases in each group.After admission,both groups were given routine basic treatment;the contro group was treated with cimetidine injection,and the treatment group was additionally treated with Danshao tang based on the treatment of the control group.Both groups were treated for two courses,with 10 days being a course.The clinical effects in the two groups were compared;the changes of Chinese medicine syndrome scores and immune function indexes including CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)before and after treatment in the two groups were compared;the remission time of clinical symptoms after treatment in the two groups was observed.Results:After treatment,the total effective rate of clinical effect was 94.12%in the treatment group and 76.47%in the control group,the difference being significant(P<0.05).After treatment,Chinese medicine syndrome scores in the two groups were decreased when compared with those before treatment,and the score in the treatment group was lower than that in the control group,differences being significant(P<0.05).After treatment,the disappearance time of rash,pruritus and skin pain in the treatment group was shorter than that in the control group,differences being significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the two groups were increased when compared with those before treatment,and the levels of CD8^(+)were decreased,differences being significant(P<0.05).After treatment,the levels of CD3^(+),CD4^(+)and CD4^(+)/CD8^(+)in the treatment group were higher than those in the control group,and CD8^(+)level was lower,differences being significant(P<0.05).Conclusion:The clinical appli

关 键 词：皮肤型过敏性紫癜 小儿 丹芍汤 西咪替丁注射液 免疫功能 

分 类 号：R725.5[医药卫生—儿科]