Peptaibols:Diversity, bioactivity, and biosynthesis  

作　　者：Xuewen Hou Ruonan Sun Yanyan Feng Runfang Zhang Tianjiao Zhu Qian Che Guojian Zhang Dehai Li 

机构地区：[1]Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China [2]Laboratory for Marine Drugs and Bioproducts,Pilot National Laboratory for Marine Science and Technology,Qingdao 266237,China [3]Marine Biomedical Research Institute of Qingdao,Qingdao 266101,China

出　　处：《Engineering Microbiology》2022年第3期1-12,共12页工程微生物学（英文）

基　　金：This work was funded by National Natural Science Foundation of China(Nos.41976105,81991522);Taishan Scholar Youth Expert Pro-gram in Shandong Province(No.tsqn 202103153);Major Basic Re-search Programs of Natural Science Foundation of Shandong Province(No.ZR2019ZD18);the Fundamental Research Funds for the Cen-tral Universities(No.201941001);the NSFC-Shandong Joint Fund(No.U1906212);the Marine S&T Fund of Shandong Province for Pi-lot National Laboratory for Marine Science and Technology(Qingdao)(No.2018SDKJ0401-2);the Youth Innovation Plan of Shandong province(No.2019KJM004).

摘　　要：Peptaibols are a large family of linear,amphipathic polypeptides consisting of 5-20 amino acid residues gener-ated from the fungal nonribosomal peptide synthetase(NRPS)pathway.With a relatively high content of non-proteinogenic amino acids such as𝛼-aminoisobutyrate(Aib)and isovaline(Iva)in the skeleton,peptaibols exhibit a wide range of biological activities,including anti-microbial,cytotoxic,and neuroleptic effects.With five peptai-bols brought to market for use as biocontrol agents,this class of peptides has received increasing attention from both biochemists and pharmacologists.In this review,we summarized the progress made in structural character-ization,elucidation of biosynthetic pathways,and investigation of biosynthesis elucidation and bioactivities,to promote further efforts to develop peptaibols as pharmaceuticals.

关 键 词：PEPTAIBOLS Structural diversity Bioactivity anti-infection BIOSYNTHESIS 

分 类 号：Q93[生物学—微生物学]