Hippo-YAP信号通路在运动性心肌肥大中的调控作用  

The regulatory role of Hippo-YAP signaling pathway in exercise-induced cardiac hypertrophy

作　　者：范清华 齐洁[1] 张钧[1] Fan Qinghua;Qi Jie;Zhang Jun(Institute of Physical Education,Shanghai Normal University,Shanghai 200234,China)

机构地区：[1]上海师范大学体育学院,上海市200234

出　　处：《中国组织工程研究》2023年第17期2708-2715,共8页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(32071170),项目负责人:张钧。

摘　　要：背景:Hippo-YAP信号通路是一种在不同物种间高度保守的信号级联,在影响生理性心肌肥大的研究中引发广泛关注。研究发现,众多途径如机械力、自噬、能量代谢参与调控运动性心肌肥大,这些途径可能在运动后与Hippo-YAP信号通路发生相互作用,从而影响运动性心肌肥大的形成和发展。目的:总结运动对Hippo-YAP信号通路的影响,阐述Hippo-YAP信号通路在调控运动性心肌肥大中的潜在机制。方法:以“Hippo-YAP信号通路、YAP/TAZ、运动性心肌肥大、心脏、运动”为中文检索词,以“Hippo-YAP signaling pathway,YAP/TAZ,exercise-induced cardiac hypertrophy,physiological hypertrophy,heart,exercise”为英文检索词,检索1983-2022年分别收录在中国知网、PubMed和Web of Science数据库的相关文献,对符合筛选标准的70篇文献进行综述。结果与结论:Hippo-YAP信号通路受到运动的影响,并且在运动诱导的生理性心肌肥大中具有一定的调控作用。①Hippo-YAP信号通路感应运动触发的机械力刺激,导致YAP/TAZ活性和表达发生改变,介导心肌细胞对机械信号的应答。②Hippo-YAP信号通路调节心肌细胞自噬,维护运动中心肌细胞内环境稳态和正常的结构及生理功能。③Hippo-YAP信号通路可能参与运动性心肌肥大发生过程中能量物质的氧化和糖酵解反应,也可能受到运动期间能量变化的影响。④Hippo-YAP信号通路可能在运动的作用下加强与某些生理性心肌肥大相关ncRNA的联系,多种ncRNA可能共同调节Hippo-YAP信号传导。⑤Hippo-YAP信号通路与胰岛素生长因子1/胰岛素生长因子受体等运动性心肌肥大经典途径发生相互作用,运动促进它们之间的信号传导交互,参与调控运动性心肌肥大。⑥深入研究Hippo-YAP信号通路在运动性心肌肥大中的调控作用,有助于深化对运动促进心脏健康的理解,为临床防治心脏疾病和心肌组织构建提供新的思路和策�BACKGROUND:The Hippo-YAP signaling pathway is a signaling cascade that is highly conserved across species and has attracted widespread attention in the study of physiological cardiac hypertrophy.Studies have found that many pathways such as mechanical force,autophagy,and energy metabolism are involved in the regulation of exercise-induced cardiac hypertrophy.These pathways may interact with the Hippo-YAP signaling pathway after exercise,thereby affecting the formation and development of exercise-induced cardiac hypertrophy.OBJECTIVE:To summarize the effects of exercise on Hippo-YAP signaling pathway,and describe the potential mechanism of Hippo-YAP signaling pathway in regulating exercise-induced cardiac hypertrophy.METHODS:“Hippo-YAP signaling pathway,YAP/TAZ,exercise-induced cardiac hypertrophy,heart,exercise”were used as keywords in Chinese and English.Relevant literatures included in CNKI,PubMed,and Web of Science databases from 1983 to 2022 were retrieved,and 70 articles that met the screening criteria were reviewed.RESULTS AND CONCLUSION:Hippo-YAP signaling pathway is affected by exercise and has a certain regulatory role in exercise-induced physiological cardiac hypertrophy.(1)Hippo-YAP signaling pathway induces mechanical stimulation triggered by exercise,which leads to changes in the activity and expression of YAP/TAZ,and mediates the response of cardiomyocytes to mechanical signals.(2)Hippo-YAP signaling pathway regulates autophagy in cardiomyocytes and maintains the homeostasis,normal structures and physiological functions of cardiomyocytes during exercise.(3)Hippo-YAP signaling pathway may mediate the oxidation and glycolysis of energy substances during exercise-induced cardiac hypertrophy,and may also be affected by energy changes during exercise.(4)Hippo-YAP signaling pathway may strengthen the connection with some non-coding RNAs related to physiological cardiac hypertrophy under the action of exercise,and multiple non-coding RNAs may jointly regulate Hippo-YAP signaling.(5)Hippo-YAP signaling

关 键 词：Hippo-YAP信号通路 激酶级联 YAP/TAZ 运动性心肌肥大 心肌细胞 心脏 运动 综述 

分 类 号：R452[医药卫生—治疗学] R363[医药卫生—临床医学] R364