岭南地区痛风患者血尿酸与血脂比值关系及中药用药规律研究  

Study on the Relationship between Blood Uric Acid and Blood Lipid Ratio and the Medication Rules of Chinese Medicine for Gout Patients in Lingnan Area

作　　者：王馨玉 何家颖 李淑瑶 关彤[2] WANG Xin-Yu;HE Jia-Ying;LI Shu-Yao;GUAN Tong(Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405 Guangdong,China)

机构地区：[1]广州中医药大学,广东广州510405 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《广州中医药大学学报》2022年第10期2273-2279,共7页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】探讨岭南地区痛风患者血尿酸(BUA)水平与血脂比值的相关性,寻找痛风中药用药规律,为指导痛风临床中医诊疗提供客观证据。【方法】采用回顾性分析方法,选取2019年1月至2021年12月在广州中医药大学第一附属医院住院治疗,明确诊断为痛风的患者,共99例。根据血脂情况将入组患者分为胆固醇(TC)和甘油三酯(TG)均正常组(简称血脂正常组)42例、单纯TC升高组(TC升高组)14例、单纯TG升高组(TG升高组)27例、TC和TG均升高组(血脂升高组)16例。收集并整理患者的一般资料及相关实验室指标,分析BUA水平与红细胞沉降率(ESR)、C反应蛋白(CRP)、TC、TG、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)及血脂比值[TC/HDL-C、TG/HDL-C、LDL-C/HDL-C]的相关性;同时收集中药处方资料,并运用中医传承辅助平台V2.5对中药用药规律进行分析。【结果】(1)TC升高组及血脂升高组的TC/HDL-C、LDL-C/HDL-C明显高于血脂正常组,差异均有统计学意义(P<0.05),而HDL-C、TG/HDL-C、ESR、CRP与血脂正常组比较,差异均无统计学意义(P>0.05);TG升高组的TC/HDL-C、TG/HDL-C、LDL-C/HDL-C明显高于血脂正常组,差异均有统计学意义(P<0.05),而HDL-C、ESR、CRP与血脂正常组比较,差异均无统计学意义(P>0.05)。(2)Pearson相关分析提示,痛风患者BUA与LDL-C/HDL-C、TC/HDL-C呈正相关,差异均有统计学意义(P<0.01);BUA与ESR、CRP、TC、TG、LDL-C、HDL-C、TG/HDL-C无明显相关性,差异均无统计学意义(P>0.05)。(3)共纳入99例患者的临床有效处方,涉及中药131味,用药频次最高的前5味中药依次为薏苡仁、甘草、牛膝、绵萆薢、苍术。共提取23个核心组合和23个关联度较高的用药组合,并演化得到13首治疗痛风的新处方,新方中用药种类较多,清热药、祛风湿药、利水渗湿药、活血药等均有不同程度的使用。【结论】痛风患者BUA与血脂比值密切相关,血脂比值Objective To investigate the correlation of blood uric acid(BUA)level with blood lipid ratio in gout patients in Lingnan area,and to explore the Chinese medicine medication rules for gout,so as to provide objective evidence to guide the clinical treatment with Chinese medicine.Methods A total of 99 patients who were hospitalized at the First Affiliated Hospital of Guangzhou University of Chinese Medicine from January 2019 to December 2021 with the confirmed diagnosis of gout were enrolled into the retrospective analysis.The enrolled patients were divided according to their lipid profiles into normal cholesterol(TC)and triglycerides(TG)group(42 cases),elevated TC group(14 cases with only the elevation of TC),elevated TG group(27 cases with only the elevation of TG),and elevated TC and TG group(16 cases with the elevation of both TC and TG).The general data and relevant laboratory indexes of the patients were collected and analyzed.The correlation of BUA levels with erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),TC,TG,low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)and blood lipid ratio of TC/HDL-C,TG/HDL-C,and LDL-C/HDL-C was analyzed.Meanwhile,the Chinese medicine prescription data were also collected to explore the medication rules of Chinese medicine for gout by using the Traditional Chinese Medicine Inheritance Support System(TCMISS)V2.5.Results(1)The ratios of TC/HDL-C and LDL-C/HDL-C in the elevated TC group and the elevated TC and TG group were significantly higher than those in normal TC and TG group,and the differences were statistically significant(P<0.05).However,HDL-C,TG/HDL-C,ESR,and CRP in the elevated TC group and the elevated TC and TG group were not statistically different from those in normal TC and TG group(P>0.05).The elevated TG group had higher ratios of TC/HDL-C,TG/HDL-C,and LDL-C/HDL-C than the normal TC and TG group,and the differences were statistically significant(P<0.05).But the differences of HDL-C,ESR,and CRP between the elevated TG g

关 键 词：岭南地区 痛风 尿酸 血脂比值 数据挖掘 中医传承辅助平台 用药规律 

分 类 号：R259.897[医药卫生—中西医结合]