血清CRP、WBC、PCT、CD64指数联合检验在妇科感染性疾病中的诊断价值  

Value of combined detection of serum CRP,WBC,PCT and CD64 index in diagnosis of gynecological infectious diseases

作　　者：金璐 丁芳芳 胡丹 JIN Lu;DING Fang-fang;HU Dan(Department of Clinical Laboratory,Shenyang Seventh People's Hospital,Shenyang 110003,China)

机构地区：[1]沈阳市第七人民医院检验科,110003

出　　处：《中国现代药物应用》2022年第17期86-89,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨C反应蛋白(CRP)、白细胞计数(WBC)、降钙素原(PCT)、CD64指数联合检验在妇科感染性疾病诊断中的应用价值。方法150例妇科感染性疾病患者,依据感染类型分为细菌组(细菌性感染,80例)与真菌组(真菌性感染,70例)。另选取同期在本院接受体检的150例健康女性作为对照组。检测三组血清PCT、CRP、WBC、CD64指数水平。比较三组及不同类型妇科感染性疾病患者血清PCT、CRP、WBC、CD64指数水平,并分析血清PCT、CRP、WBC、CD64指数对妇科感染性疾病的诊断价值。结果细菌组血清CRP、WBC、CD64指数水平均高于真菌组与对照组,且真菌组血清CRP、WBC、CD64指数水平均高于对照组,差异均有统计学意义(P<0.05)。细菌组、真菌组血清PCT水平均高于对照组,差异均有统计学意义(P<0.05)。不同妇科感染性疾病中,附件炎患者的CRP水平最高,为(123.04±12.24)mg/L;子宫内膜炎患者的PCT水平最高,为(7.71±0.75)μg/L;阴道炎患者的WBC水平最高,为(19.53±2.73)×10^(9)/L;宫颈糜烂患者的CD64指数最高,为(13.73±1.46)。在妇科感染性疾病的诊断中,PCT的敏感性最高,为91%;CD64指数的特异性最高,为89%。联合诊断的特异性为95%,敏感性为97%。四项指标联合检测对妇科感染性疾病诊断的敏感性和特异性均高于单一指标。结论血清CRP、WBC、PCT、CD64指数是反应感染性疾病的敏感性指标,联合检测可准确鉴别妇科感染性疾病的感染类型,对真菌感染和细菌感染进行鉴别诊断,指导临床治疗方案的选择,对妇科感染性疾病进行早期诊断具有重要的诊断价值。Objective To discuss the application value of combined detection of serum C-reactive protein(CRP),white blood cell count(WBC),procalcitonin(PCT)and CD64 index in diagnosis of gynecological infectious diseases.Methods 150 patients with gynecological infectious diseases were divided into bacterial group(bacterial infection,80 cases)and fungal group(fungal infection,70 cases)according to the type of infection.Another 150 healthy women who received physical examination in our hospital during the same period were selected as the control group.The serum PCT,CRP,WBC,CD64 index levels of the three groups were tested.The levels of serum PCT,CRP,WBC and CD64 index in three groups as well as patients with different types of gynecological infectious diseases were compared to analyze diagnostic value of serum PCT,CRP,WBC and CD64 index for gynecological infectious diseases.Results The levels of serum CRP,WBC,and CD64 index in the bacterial group were higher than those in the fungal group and the control group,and the levels of serum CRP,WBC,and CD64 index in the fungal group were higher than those in the control group,and the differences were statistically significant(P<0.05).The serum PCT levels in the bacterial group and the fungal group were higher than those in the control group,and the differences were statistically significant(P<0.05).Among different gynecolonical infectious diseases,patients with adnexitis had the highest CRP level of(123.04±12.24)mg/L;patients with endometritis had the highest PCT level of(7.71±0.75)μg/L;patients with vaginitis had the highest WBC level of(19.53±2.73)×10^(9)/L;patients with cervical erosion had the highest CD64 index of(13.73±1.46).In the diagnosis of gynecological infectious diseases,PCT had the highest sensitivity of 91%,the CD64 index had the highest specificity of 89%.The specificity of the combined diagnosis was 95%and the sensitivity was 97%.The sensitivity and specificity of the combined test of the four indicators for the diagnosis of gynecological infectious diseases we

关 键 词：妇科感染性疾病 C反应蛋白 白细胞计数 降钙素原 CD64指数 

分 类 号：R711.3[医药卫生—妇产科学]