中心静脉导管引流联合尿激酶注入治疗结核性胸膜炎的效果分析  

Effect analysis of central venous catheter drainage combined with urokinase injection in the treatment of tuberculous pleurisy

作　　者：张丽姣 ZHANG Li-jiao(Liaoyang Chest Hospital,Liaoyang 111005,China)

机构地区：[1]辽宁省辽阳市胸科医院,111005

出　　处：《中国现代药物应用》2022年第17期122-124,共3页Chinese Journal of Modern Drug Application

摘　　要：目的观察中心静脉导管引流联合尿激酶注入治疗结核性胸膜炎的效果。方法86例结核性胸膜炎患者,以随机分组法分为试验组和参照组,各43例。参照组予以常规治疗,试验组予以中心静脉导管引流联合尿激酶注入治疗。比较两组患者的临床疗效,腹水基本吸收时间、胸腔积液引流时间、胸腔积液引流量以及胸膜厚度,治疗前后的肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)]水平,并发症发生情况。结果试验组患者的治疗总有效率93.02%明显高于参照组的76.74%,差异具有统计学意义(P<0.05)。试验组患者的腹水基本吸收时间(6.78±1.32)d、胸腔积液引流时间(7.03±1.24)d均短于参照组的(7.44±1.35)、(7.93±1.27)d,胸腔积液引流量(2435.87±327.62)ml、胸膜厚度(1.09±0.16)mm均小于参照组的(2586.78±320.43)ml、(1.32±0.14)mm,差异具有统计学意义(P<0.05)。治疗后,试验组患者的FVC(3.06±0.68)L与FEV1(2.79±0.46)L均大于参照组的(2.76±0.65)、(2.28±0.45)L,差异具有统计学意义(P<0.05)。试验组患者的并发症发生率4.65%明显低于参照组的18.60%,差异具有统计学意义(P<0.05)。结论在结核性胸膜炎的临床治疗中,应用中心静脉导管引流联合尿激酶注入治疗的效果更为理想,存在临床实施、推广价值。Objective To observe the effect of central venous catheter drainage combined with urokinase injection in the treatment of tuberculous pleurisy.Methods A total of 86 patients with tuberculous pleurisy were randomly divided into experimental group and reference group,with 43 cases in each group.The reference group was treated with routine treatment,while the experimental group was treated with central venous catheter drainage combined with urokinase infusion.Both groups were compared in terms of clinical efficacy,basic absorption time of ascites,drainage time of pleural effusion,drainage volume of pleural effusion and pleural thickness,and pulmonary function indexes[forced vital capacity(FVC),forced expiratory volume in the 1st second(FEV1)]before and after treatment,and incidence of complications.Results The total effective rate in the experimental group was 93.02%,which was significantly higher than 76.74% in the reference group,and the difference was statistically significant(P<0.05).The basic absorption time of ascites(6.78±1.32)d and drainage time of pleural effusion(7.03±1.24)d in the experimental group were shorter than(7.44±1.35)and(7.93±1.27)d in the control group;the drainage volume of pleural effusion(2435.87±327.62)ml and pleural thickness(1.09±0.16)mm in the experimental group were smaller than(2586.78±320.43)ml and(1.32±0.14)mm in the reference group;all the differences were statistically significant(P<0.05).After treatment,the FVC(3.06±0.68)L and FEV1(2.79±0.46)L of the experimental group were higher than(2.76±0.65)and(2.28±0.45)L of the reference group,and the differences were statistically significant(P<0.05).The incidence of complications in the experimental group was 4.65%,which was significantly lower than 18.60%in the reference group,and the difference was statistically significant(P<0.05).Conclusion Central venous catheter drainage combined with urokinase injection has ideal effect in clinical treatment of tuberculous pleurisy,which has clinical implementation and promotion value.

关 键 词：中心静脉导管引流 尿激酶 结核性胸膜炎 

分 类 号：R521.7[医药卫生—内科学]