可见光诱导邻烯基甲酰苯胺环化合成2-喹啉酮  

Visible Light Induced Cyclization of O-Alkenylcarboxanilide to 2-Quinolinone

作　　者：张晓斐 刘佳鑫 ZHANG Xiaofei;LIU Jiaxin(Key Laboratory of Chemical Additives for China National Light Industry,College of Chemistry&Chemical Engineering,Shaanxi University of Science and Technology,Xi’an 710021,China)

机构地区：[1]陕西科技大学化学与化工学院,中国轻工业轻化工助剂重点实验室,西安710021

出　　处：《高等学校化学学报》2022年第10期204-210,共7页Chemical Journal of Chinese Universities

基　　金：陕西省自然科学基金(批准号:2021JQ-534)资助.

摘　　要：使用廉价易得的邻烯基甲酰苯胺在可见光的诱导下发生自由基环化反应,以良好至优秀的产率合成了15种2-喹啉酮衍生物.该方法简单高效、条件温和、产率较高,具有优异的官能团兼容性,不仅拓展了邻烯基甲酰苯胺参与的新型有机反应,也为光催化合成喹啉酮类化合物提供了一条新途径.A free radical cyclization reaction induced by visible light using cheap and readily available O-alkenylfor⁃manilide was developed.The strategy was used to synthesize fifteen 2-quinolinone derivatives in good to excellent yields.This method is simple and efficient,with mild conditions and excellent functional group compatibility.Mean⁃while,a plausible mechanism is proposed on the basis of several mechanistic experiments and literature precedents.This method not only provides a new type of organic reaction involving O-alkenylformylanilide,but also provides a new pathway for the photocatalytic synthesis of quinolinones.

关 键 词：自由基环化 可见光诱导 2-喹啉酮 

分 类 号：O626[理学—有机化学]