弥散张量成像技术在大脑白质类疾病中的应用  

Application of diffusion tensor imaging technique in white matter disease

作　　者：秦嗣钧 李翔 徐云峰 魏本征[1,2] QIN Sijun;LI Xiang;XU Yunfeng;WEI Benzheng(Medical Artificial Intelligence Research Center,Shandong University of Traditional Chinese Medicine,Qingdao 266112,China;Qingdao Academy of Chinese Medicine,Shandong University of Chinese Medicine,Qingdao 266112)

机构地区：[1]山东中医药大学医学人工智能研究中心,青岛266112 [2]山东中医药大学青岛中医药科学院,青岛266112

出　　处：《生物医学工程研究》2022年第3期324-331,共8页Journal Of Biomedical Engineering Research

基　　金：国家自然科学基金资助项目(61872225);山东省自然科学基金资助项目(ZR2020KF013,ZR2020ZD44,ZR2019ZD04,ZR2020QF043);山东省高校青创引才育才计划项目(2019-173);齐鲁卫生与健康领军人才培育工程资助项目。

摘　　要：弥散张量成像(diffusion tensor imaging, DTI)是一项在生物体内显示大脑白质变化的新兴脑影像技术。因其无创、高效,在大脑白质类疾病辅助诊断方面得到了广泛应用。本文主要介绍了DTI技术的成像原理与分析方法,简要总结与分析了DTI技术在大脑白质类疾病辅助诊断中的研究进展与临床应用,并针对目前DTI技术在大脑白质类疾病研究中存在的挑战提出了新的研究思路及方向,对大脑白质类疾病的深入研究具有一定的参考意义。Diffusion Tensor Imaging(DTI) is an emerging brain imaging technology that can show the changes of brain fiber tracts in the focal areas of cerebral white matter diseases in vivo.It has been widely used in the auxiliary diagnosis of cerebral white matter diseases due to its non-invasive and efficient characteristics. We mainly introduce the imaging principle and data processing method of DTI technology. The research progress and clinical application of DTI technique in the auxiliary diagnosis of cerebral white matter diseases are systematically summarized and analyzed. Finally, new research ideas and directions are proposed in view of the current challenges of DTI technology in brain white matter diseases, which has certain reference significance for the in-depth study of brain white matter diseases.

关 键 词：弥散张量成像 疾病诊断 脑白质 磁共振成像 认知功能障碍 纤维束追踪 

分 类 号：R318[医药卫生—生物医学工程] R331[医药卫生—基础医学] R445