基于机体状态和功能因素探讨药物诱导肝损伤的研究进展  

Research progress on discussion of factors influencing drug-induced liver injury based on organismal status and function

作　　者：蔡琼 杨星月[3] 李芝奇 范琦琦 陈美琳 戴胜云 林瑞超[1] 赵崇军[1] CAI Qiong;YANG Xing-yue;LI Zhi-qi;FAN Qi-qi;CHEN Mei-lin;DAI Sheng-yun;LIN Rui-chao;ZHAO Chong-jun(Beijing Key Laboratory for Quality Evaluation of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 102488,China;China National Institute for Food and Drug Control,Beijing 102629,China;Beijing University of Chinese Medicine,Beijing 102488,China)

机构地区：[1]北京中医药大学中药品质评价北京市重点实验室,北京102488 [2]中国食品药品检定研究院,北京102629 [3]北京中医药大学,北京102488

出　　处：《中草药》2022年第17期5523-5530,共8页Chinese Traditional and Herbal Drugs

基　　金：国家科技重大专项(2018ZX09735005);公益性行业科研专项(2015070042);北京中医药大学新教师启动基金资助项目(2020-JYBXJSJJ-009)。

摘　　要：药物性肝损伤(drug-induced liver injury,DILI)是急性肝衰竭和药物退出市场的主要原因。大量研究已经从药物的理化性质、体内代谢和作用机制等方面对DILI进行深入研究,为药物研发提供了充分的生物信息。即便如此,DILI尤其是中药诱导肝损伤事件依旧时有发生。机体与药物的相互影响和作用是DILI发生的主要因素。因此,从临床患者和实验动物等角度入手,系统整理和分析不同影响因素,如生活习惯、生理病理状态,年龄、遗传差异、性别等对DILI的影响,评价其与DILI之间的关系,以期为未来中药系统安全性评价技术和方法的完善、中药安全使用提供参考。Drug-induced liver injury(DILI) is a major cause of acute liver failure and drug withdrawal from the market. Numerous studies have been conducted to investigate DILI in depth in terms of the physicochemical properties, in vivo metabolism and mechanism of action of drugs, providing sufficient biological information for drug development. Even so, incidents of DILI, especially herbalinduced liver injury, continue to occur. The interaction and effect of organism and drug is the main factor in the occurrence of DILI.Therefore, the effects of different influencing factors, such as lifestyle habits, physiopathological status, age, genetic differences,gender, etc. on DILI from the perspectives of clinical patients and experimental animals were systematically collected and analyzed in this paper, and the relationship between them and DILI was evaluated, in order to provide a reference for the improvement of systematic safety evaluation techniques and methods of traditional Chinese medicine and the safe use of traditional Chinese medicine in the future.

关 键 词：中药 肝毒性 机体功能 生活习惯 生理病理状态 年龄 遗传差异 性别差异 

分 类 号：R285.53[医药卫生—中药学]