参芪降糖颗粒防治糖脂代谢紊乱性疾病研究进展  

Research progress on Shenqi Jiangtang Granules in prevention and treatment of glucolipid metabolic diseases

作　　者：洪佳娜 程国良 黄志伟 黄文静 王乐琪 李冰 张贵民 肖雪 罗国安 HONG Jia-na;CHENG Guo-liang;HUANG Zhi-wei;HUANG Wen-jing;WANG Le-qi;LI Bing;ZHANG Gui-min;XIAO Xue;LUO Guo-an(Institute of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Guangdong Metabolic Disease Research Center of Integrated Chinese and Western Medicine,Guangzhou 510006,China;Key Laboratory of Glucolipid Metabolic Disorder,Ministry of Education,Guangzhou 510006,China;Guangdong Key Laboratory of Metabolic Disease Prevention and Treatment of Traditional Chinese Medicine,Guangzhou 510006,China;State Key Laboratory of Generic Manufacture Technology of Chinese Traditional Medicine,Linyi 276000,China;Department of Chemistry,Tsinghua University,Beijing 100084,China)

机构地区：[1]广东药科大学中医药研究院,广东广州510006 [2]广东省代谢病中西医结合研究中心,广东广州510006 [3]糖脂代谢病教育部重点实验室,广东广州510006 [4]广东省代谢性疾病中医药防治重点实验室,广东广州510006 [5]中药制药共性技术国家重点实验室,山东临沂276000 [6]清华大学化学系,北京100084

出　　处：《中草药》2022年第17期5544-5552,共9页Chinese Traditional and Herbal Drugs

基　　金：国家重点研发计划项目(2018YFC1704200);国家重点研发计划项目(2018YFC1704205);广东省基础与应用基础研究重大项目(2019B030302005)。

摘　　要：参芪降糖颗粒由人参(茎叶)皂苷、黄芪等11味中药组成,具有降糖、抗炎、保护微血管等多种药理活性。因参芪降糖颗粒具有协同降糖,改善糖尿病患者症状和体征,提高生活质量的作用,《中国2型糖尿病防治指南(2020年版)》推荐其应用于糖尿病防治。对参芪降糖颗粒的药理作用及临床应用等进行总结,基于糖脂代谢病创新理论提出对参芪降糖颗粒防治疾病的认识,以期为参芪降糖颗粒的深入研究与临床推广提供科学支持。Shenqi Jiangtang Granules(参芪降糖颗粒)is composed of eleven kinds of traditional Chinese medicines including total ginsenosides of Panax ginseng stems and leaves and Huangqi(Astragali Radix),etc.It has a variety of pharmacological effects,including hypoglycemic effects,anti-inflammation,and microvasculature protection and so on.Shenqi Jiangtang Granules has the effects of synergistically lowering glucose,improving the symptoms and signs of diabetic patients,and improving the quality of life.Therefore,Shenqi Jiangtang Granules is recommended by“Guidelines for the Prevention and Treatment of Type 2 Diabetes in China(2020 edition)”for application in the prevention and treatment of diabetes.The pharmacological action and clinicalapplication of Shenqi Jiangtang Granules were summarized in this paper,and the understanding of prevention and treatment of Shenqi Jiangtang Granules was put forward based on the innovative theory of glycolipid metabolic disorders,in order to provide scientific support for further research and clinical practice.

关 键 词：参芪降糖颗粒 糖脂代谢紊乱性疾病 2型糖尿病 糖尿病并发症 糖脂代谢病 

分 类 号：R286.7[医药卫生—中药学]