药食同源中药调控氧化应激防治冠心病的研究进展  

Research progress on medicinal food homology traditional Chinese medicine in prevention and treatment of coronary heart disease through regulation of oxidative stress

作　　者：陈俣祯 陈芳[1,2,3] 朱建平 向茗[1,2,3] CHEN Yu-zhen;CHEN Fang;ZHU Jian-ping;XIANG Ming(Hunan University of Chinese Medicine,Changsha 410208,China;Hunan Provincial Medicine&Food Homologous Functional Food Engineering and Technology Research Center,Changsha 410208,China;Key Laboratory of TCM Cardiopulmonary Disease Syndrome Differentiation and Medicine Diet Therapy,Changsha 410208,China)

机构地区：[1]湖南中医药大学,湖南长沙410208 [2]湖南省药食同源功能性食品工程技术研究中心,湖南长沙410208 [3]中医心肺病证辨证与药膳食疗重点研究室,湖南长沙410208

出　　处：《中草药》2022年第17期5582-5592,共11页Chinese Traditional and Herbal Drugs

基　　金：湖南省自然科学基金项目(2021JJ40411);湖南省教育厅资助科研项目(18B241);湖南中医药大学药食同源工程中心开放基金资助(YSTY08)。

摘　　要：冠状动脉粥样硬化的形成与氧化应激密不可分,过量的活性氧(reactive oxygen species,ROS)损害内皮细胞、血管,进而引起氧化和抗氧化功能的失衡,造成心肌缺氧、缺血等症状。在过去数十年中,中药中抗氧化成分已广泛应用于包括冠心病和高血压在内的心血管疾病的治疗,药食同源中药因其具有天然、健康、运用广泛等特点在医药和功能食品领域备受关注。综述了药食同源中药通过调节氧化应激相关指标及信号通路预防冠心病的作用机制,以期为冠状动脉粥样硬化的预防研究和研制具有预防冠心病的药食同源产品提供参考和借鉴。The formation of coronary atherosclerosis is inextricably linked to oxidative stress. Excess reactive oxygen species(ROS)damage endothelial cells and blood vessels, which in turn causes an imbalance of oxidative and anti-oxidant functions, resulting in symptoms such as myocardial hypoxia and ischemia. In the past decades, anti-oxidant components in traditional Chinese medicines(TCMs) have been widely used in the treatment of cardiovascular diseases including coronary heart disease and hypertension, and medicinal food homology TCMs have attracted much attention in the field of medicine and functional foods because of their natural,healthy and widely used characteristics. In this paper, we review the mechanism of medicinal food homology TCMs in the prevention and treatment of coronary heart disease by regulating oxidative stress-related indicators and signaling pathways, with the aim of providing reference for the further development of coronary atherosclerosis prevention research and the development of homologous products with coronary heart disease prevention.

关 键 词：药食同源 冠心病 中药 氧化应激 活性氧 作用机制 

分 类 号：R285[医药卫生—中药学]