骨质疏松实验室诊断及影响因素专家共识2022  

Expert consensus on laboratory diagnosis and influencing factors of osteoporosis

作　　者：张萌萌 徐又佳[2] 侯建明[3] 程海涛 张岩[5] 张智海 赵国阳[7] 张东伟 史晓林 黄宏兴 葛继荣 张秀珍[12] 李英华 吴涤 吴岩[15] 杨书满 徐辉[16] 邓伟民 王永福[18] 李毅中[19] 郑洪新[20] 胡玲[21] 《骨质疏松实验室诊断及影响因素专家共识》编写组 ZHANG Mengmeng;XU Youjia;HOU Jianming;CHENG Haitao;ZHANG Yan;ZHANG Zhihai;ZHAO Guoyang;ZHANG Dongwei;SHI Xiaolin;HUANG Hongxing;GE Jirong;ZHANG Xiuzhen;LI Yinghua;WU Di;WU Yan;YANG Shuman;XU Hui;DENG Weimin;WANG Yongfu;LI Yizhong;ZHENG Hongxin;HU Ling(Chinese Journal of Osteoporosis,Beijing 100101,China;The Second Affiliated Hospital of Suzhou University,Suzhou 215008,China;Fujian Medical University Provincial School of Clinical Medicine,Fuzhou 350001;FAW General Hospital of Jilin Province,Changchun 130011;Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;Affiliated Hospital of Jiangsu University,Zhenjiang 212000,China;Diabetes Research Center,Beijing University of Chinese Medicine,Beijing 100029,China;The Second Affiliated Hospital of Zhejiang University of Chinese Medicine,Hangzhou 310005,China;The Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510240,China;Fujian Academy of Chinese Medical Sciences,Fuzhou 350003,China;Tongji Hospital Affiliated Tongji University,Shanghai 200065,China;The Fifth People’s Hospital of Shanghai,Shanghai 200240,China;Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014040,China;Inner Mongolia Medical University,Hohhot 010110,China;Jilin University,Changchun 130023,China;General Hospital of Southern Theater of the Command,Guangzhou 510010,China;The First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology,Baotou 014010,China;The Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China;Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;The Third Affiliated Hospital of Nanchang University,Nanchang 330009,China)

机构地区：[1]《中国骨质疏松杂志》社,北京100101 [2]苏州大学附属第二医院,江苏苏州215008 [3]福建医科大学省立临床医学院,福建福州350001 [4]吉林省一汽总医院,吉林长春130011 [5]上海中医药大学附属龙华医院,上海200032 [6]中国中医科学院广安门医院,北京100053 [7]江苏大学附属医院,江苏镇江212000 [8]北京中医药大学糖尿病研究中心,北京100029 [9]浙江中医药大学附属第二医院,浙江杭州310005 [10]广州中医药大学第三附属医院,广东广州510240 [11]福建省中医药科学院,福建福州350003 [12]同济大学附属同济医院,上海200065 [13]上海市第五人民医院,上海200240 [14]内蒙古科技大学包头医学院,内蒙古包头014040 [15]内蒙古医科大学,内蒙古呼和浩特010110 [16]吉林大学,吉林长春130023 [17]中国人民解放军南部战区总医院,广东广州510010 [18]内蒙古科技大学包头医学院第一附属医院,内蒙古包头014010 [19]福建医科大学附属第二医院,福建泉州362000 [20]辽宁中医药大学,辽宁沈阳110847 [21]南昌大学第三附属医院,江西南昌330009 [22]不详

出　　处：《中国骨质疏松杂志》2022年第9期1249-1259,共11页Chinese Journal of Osteoporosis

摘　　要：骨质疏松实验室诊断是通过对血液、组织液、细胞、蛋白、活体组织等进行实验分析,科学评价和判断全身骨代谢的动态变化及骨代谢的活性,对骨质疏松临床诊断与鉴别诊断、疗效观察,以及骨代谢疾病的调控机制研究具有重要意义。课题组以《原发性骨质疏松症诊疗指南(2017)》为依据,研讨骨质疏松实验室诊断的基本检查项目、骨转换指标、鉴别诊断检查项目,旨在促进骨质疏松实验室诊断技术的推广应用。骨质疏松实验室诊断,应做好室内质量控制,减少批间误差。在进行连续监测和疗效判定时,应使用同一检测系统进行,以保证测定结果的可比性,严格规范检测流程,建立科学参考范围,减少影响因素的产生,更好应用于临床诊断、疗效评价和科学研究工作。The experimental diagnosis of osteoporosis is to scientifically evaluate and judge the dynamic changes of bone metabolism and the activity of bone metabolism through the experimental analysis of blood, tissue fluid, cells, proteins and living tissues. It has great significance for the clinical diagnosis, differential diagnosis, treatment and observation of osteoporosis and the study of the regulation mechanism of bone metabolism diseases. This paper based on the diagnosis and treatment guide for primary osteoporosis, discusses the basic laboratory examination items, bone turnover indexes and differential diagnosis examination items of osteoporosis laboratory diagnosis, in order to promote the popularization and application of osteoporosis experimental diagnosis technology. In the laboratory diagnosis of osteoporosis, indoor quality control should be done well to reduce inter batch error. During continuous monitoring and efficacy determination, the same detection system should be used to ensure the comparability of measurement result, strictly standardize the detection process, establish a scientific reference range, reduce the generation of influencing factors, and better apply it to clinical diagnosis, efficacy evaluation and scientific research.

关 键 词：骨质疏松 实验室诊断 基本实验室检查项目 骨转换指标 鉴别诊断检查项目 影响因素 

分 类 号：R44[医药卫生—诊断学]