白藜芦醇在骨关节炎中的作用及机制研究进展  

Research progress on the role and mechanism of resveratrol in osteoarthritis

作　　者：褚云峰[1] 于红燕 杨琪 彭艳斌[1] 陈仲 刘明 于斐[1,3] CHU Yunfeng;YU Hongyan;YANG Qi;PENG Yanbin;CHEN Zhong;LIU Ming;YU Fei(Peking University Shenzhen Hospital,Shenzhen 518036,China;Bincheng District Municipal Hospital,Binzhou 256600,China;National&Local Joint Engineering Research Center of Orthopaedic Biomaterials,Shenzhen 518036,China)

机构地区：[1]北京大学深圳医院,广东深圳518036 [2]滨州市滨城区市立医院,山东滨州256600 [3]骨科生物材料国家地方联合工程研究中心,广东深圳518036

出　　处：《中国骨质疏松杂志》2022年第9期1351-1355,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82102568,82102076,82172432,82001319);广东省基础与应用基础研究基金(2021A1515012586,2019A1515110983,2019A1515011290);白求恩·石药骨质疏松科研基金项目(G-X-2020-1107-21);北京大学深圳医院科研启动金项目(KYQD2021099)。

摘　　要：骨关节炎(osteoarthritis, OA)是由衰老、肥胖、创伤、遗传等多因素引起的慢性退行性疾病,是临床上骨科医生面临的棘手疾病,该病给患者及其家庭带来了沉重的负担。白藜芦醇是一种具有抗炎、抗氧化等作用的天然化合物,可通过影响软骨衰老、软骨基质代谢、软骨损伤等作用参与OA的发生发展进程,这一过程可能与核因子-κB(NF-κB)、Toll样受体4(TLR4)、细胞外信号调节激酶(ERK)等信号通路的调控有关。本文拟就白藜芦醇在OA进程中的作用及其可能机制的研究进展作一综述,以期为相关研究提供参考。Osteoarthritis(OA) is a chronic degenerative disease caused by aging, obesity, trauma, heredity and other factors, which is a difficult disease faced by orthopedic doctors in clinic, and brings a heavy burden to patients and families. Resveratrol is a natural compound with anti-inflammatory and antioxidant effects. It can affect cartilage aging, cartilage matrix metabolism, and cartilage injury in participate in the process of OA, which might be related to NF-κB, TLR4 and ERK signaling pathway. This paper reviews the research progress of resveratrol in the process of OA and its possible mechanism, so as to facilitate relevant research.

关 键 词：骨关节炎 白藜芦醇 软骨退化 信号通路 机制研究 

分 类 号：R684.3[医药卫生—骨科学]