微管调控成骨细胞功能的研究进展  

Research progress on MT regulating of osteoblast function

作　　者：万超超 曹林忠[1,2] 王多贤 蒋玮 张琪 刘孟初 马学强 杨博 马成祥 WAN Chaochao;CAO Linzhong;WANG Duoxian;JIANG Wei;ZHANG Qi;LIU Mengchu;MA Xueqiang;YANG Bo;MA Chengxiang(Gansu University of Traditional Chinese Medicine,Lanzhou 730000 China;Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃中医药大学附属医院,甘肃兰州730099

出　　处：《中国骨质疏松杂志》2022年第9期1360-1364,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(81860859,82160915)。

摘　　要：成骨细胞是一类具有成骨潜能的细胞,在骨稳态及骨重建的维持过程中具有重要作用,其分化过程受多种因素的调控。微管(microtubules, MT)在成骨细胞增殖、分化、矿化和自噬等生理过程中均发挥着重要作用。近年来研究发现,微管调控成骨细胞功能与微管翻译后修饰及微管相关蛋白介导的微管动态重组密切相关,但其具体机制尚未完全明了。本文拟对微管调控成骨细胞功能的研究进展作一综述。Osteoblasts are a kind of cells with osteogenic potential, which play an important role in the maintenance of bone homeostasis and bone remodeling, and their differentiation process is regulated by many factors. Microtubules(MT) play an important role in the physiological processes of osteoblast proliferation, differentiation, mineralization and autophagy. In recent years, it has been found that microtubule regulation of osteoblast function is closely related to microtubule post-translational modification and microtubule dynamic recombination mediated by microtubule binding protein, but its specific mechanism is not fully understood. This paper reviews the research progress of microtubule regulating osteoblast function.

关 键 词：微管 成骨细胞 初级纤毛 机械信号 自噬 

分 类 号：R589.5[医药卫生—内分泌]