A specialized role played by a redox cofactor  

作　　者：Shengling Xie Lihan Zhang 

机构地区：[1]Department of Chemistry,Zhejiang University,Hangzhou 310058,Zhejiang Province,China [2]Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang Province,School of Science,Westlake University,18 Shilongshan Road,Hangzhou 310024,Zhejiang Province,China [3]Institute of Natural Sciences,Westlake Institute for Advanced Study,18 Shilongshan Road,Hangzhou 310024,Zhejiang Province,China

出　　处：《Engineering Microbiology》2022年第1期42-44,共3页工程微生物学（英文）

基　　金：supported by the National Natural Science Foundation of China(22177092,82003631);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2020R01004)to L.Z.

摘　　要：The redox cofactor𝛽-nicotinamide adenine dinucleotide(NAD)has been revealed to serve as a building block for the biosynthesis of an alkaloid natural product,altemicidin.The biosynthetic pathway investigation identified a unique pyridoxal pyrophosphate(PLP)-dependent enzyme that utilizes NAD and S-adenosylmethionine(SAM)to build the bicyclic alkaloid scaffold,opening the door for biosynthetic studies of NAD-derived natural products.

关 键 词：BIOSYNTHESIS Nicotinamide adenine dinucleotide Pyridoxal phosphate-dependent enzyme CYCLOADDITION 

分 类 号：Q93[生物学—微生物学]