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作 者:Kwangwook Kim Cynthia Jinno Peng Ji Yanhong Liu
机构地区:[1]Department of Animal Science,University of California,Davis,CA 95616,USA [2]Department of Nutrition,University of California,Davis,CA 95616,USA
出 处:《Journal of Animal Science and Biotechnology》2022年第5期1576-1590,共15页畜牧与生物技术杂志(英文版)
基 金:supported by the United States Department of Agriculture(USDA)National Institute of Food and Agriculture(NIFA),multistate projects W4002 and NC1202.
摘 要:Background:Our previous study has shown that supplementation of trace amounts of antibiotic exacerbated the detrimental effects of enterotoxigenic E.coli(ETEC)infection and delayed the recovery of pigs that may be associated with modified metabolites and metabolic pathways.Therefore,the objective of this study was to explore the impacts of trace levels of antibiotic(carbadox)on host metabolic profiles and colon microbiota of weaned pigs experimentally infected with ETEC F18.Results:The multivariate analysis highlighted a distinct metabolomic profile of serum and colon digesta between trace amounts of antibiotic(TRA;0.5 mg/kg carbadox)and label-recommended dose antibiotic(REC;50 mg/kg carbadox)on d 5 post-inoculation(PI).The relative abundance of metabolomic markers of amino acids,carbohydrates,and purine metabolism were significantly differentiated between the TRA and REC groups(q<0.2).In addition,pigs in REC group had the highest(P<0.05)relative abundance of Lactobacillaceae and tended to have increased(P<0.10)relative abundance of Lachnospiraceae in the colon digesta on d 5 PI.On d 11 PI,pigs in REC had greater(P<0.05)relative abundance of Clostridiaceae compared with other groups,whereas had reduced(P<0.05)relative abundance of Prevotellaceae than pigs in control group.Conclusions:Trace amounts of antibiotic resulted in differential metabolites and metabolic pathways that may be associated with its slow responses against ETEC F18 infection.The altered gut microbiota profiles by labelrecommended dose antibiotic may contribute to the promotion of disease resistance in weaned pigs.
关 键 词:CARBADOX Colon microbiota Enterotoxigenic Escherichia coli Metabolomics Weaned pigs
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