老年不稳定性心绞痛的中医体质分布及风险预测模型构建  

Distribution of Traditional Chinese Medicine Constitution in Patients with Senile Unstable Angina and Establishment of Risk Predictive Model for Senile Unstable Angina

作　　者：王超杰 刘甜甜 刘琪 陈晨[3] WANG Chao-Jie;LIU Tian-Tian;LIU Qi;CHEN Chen(Heilongjiang University of Chinese Medicine,Harbin 150040 Heilongjiang,China;The Seventh People’s Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200120,China;The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine,Harbin 150040 Heilongjiang,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]上海中医药大学附属第七人民医院,上海200120 [3]黑龙江中医药大学附属第二医院,黑龙江哈尔滨150040

出　　处：《广州中医药大学学报》2022年第9期1970-1977,共8页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：黑龙江省卫生计生委科研项目(编号:2018234)。

摘　　要：【目的】通过对老年人冠心病不稳定性心绞痛的调查分析,识别中医体质中与心绞痛发病有关的危险因素。【方法】调查收集黑龙江地区老年人资料,分析738例受访者的生理信息、中医体质信息与冠心病的相关因素。根据是否患冠心病不稳定性心绞痛将受访者分为健康组464例和疾病组274例,采用单因素χ^(2)分析筛选出与冠心病相关的因素,基于相关因素采用Logistic回归分析建立预测模型,并采用ROC曲线对所建立模型进行验证,绘制模型森林图实现数据可视化。【结果】(1)单因素分析结果显示,在一般资料中,健康组与疾病组的年龄、学历、家族遗传病和不良嗜好史比较,差异有统计学意义(P<0.05或P<0.01)。说明与冠心病不稳定性心绞痛发病具有显著性差异的变量有年龄、学历、家族遗传病和不良嗜好史。(2)在中医体质方面,调查结果显示,本地区老年人的中医体质以气虚质、平和质、阳虚质为主。(3)二元Logistic回归分析得出,学历、不良嗜好史、家族遗传病史、阳虚质、痰湿质、年龄与老年人不稳定性心绞痛发病具有相关性;条件Logistic分析得出,高年龄组、低学历、中医体质中的痰湿质是不稳定性心绞痛发病的重要影响因素。【结论】黑龙江地区老年人冠心病发病情况较严重;阳虚体质、痰湿体质老年人是发生不稳定性心绞痛的高危人群,应及早改善体质,预防疾病的发生。Objective To identify the risk factors associated with angina pectoris in the traditional Chinese medicine(TCM)constitution through the investigation and analysis of unstable angina in senile patients with coronary heart disease.Methods The data of the elderly in Heilongjiang province were collected.The physiological information,TCM constitution,and associated factors of coronary heart disease in 738 interviewees were analyzed.The respondents were divided into the healthy group(464 cases)and the illness group(274 cases)according to the presence of unstable angina of coronary heart disease.The factors associated with coronary heart disease were screened out using monofactor Chi-square test,a predictive model was established based on the associated factors using logistic regression analysis,and the established model was validated using ROC curves.Finally,a model forest plot was drawn to visualize the data.Results(1)The results of the univariate analysis showed that in the general data,the differences were statistically significant in the age,education level,history of familial genetic diseases and history of bad additions between the healthy group and the illness group(P<0.05 or P<0.01),indicating that the variables of age,education level,familial genetic diseases and history of bad additions were the risk factors of the onset of unstable angina of coronary artery disease.(2)In terms of TCM constitution,the survey results showed that the TCM constitution of the elderly in Heiliongjiang region was dominated by qi deficiency constitution,balanced constitution and yang deficiency constitution.(3)Binary logistic regression analysis concluded that education level,history of bad additions,history of familial genetic diseases,yang deficiency constitution,phlegm-damp constitution and age were correlated with the onset of senile unstable angina.The conditional logistic analysis concluded that the elderly group,low education level,and TCM phlegmdamp constitution were the important influencing factors for the onset of unstabl

关 键 词：冠心病不稳定性心绞痛 老年人 危险因素 中医体质 阳虚体质 痰湿体质 LOGISTIC回归分析 

分 类 号：R259.414[医药卫生—中西医结合]